some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. stiripentol (stp) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. it has poor aqueous solubilityand its solubility has to be enhanced accordingly. polyethyleneglycol 6000 (peg-6000) iscommonly utilized as a hydrophilic...

Abstract:  In this study, the change in the crystalline structure of gas hydrate was predicted for ternary mixture of methane-ethane-water. For this purpose, the tangent plane distance (TPD) minimization method was used. First, the calculations were performed for the binary mixtures of methane-water and ethane-water as the gas and liquid phases. The results show that for a binary mixture of th...

Humic substances (HS) are ubiquitous natural products of decomposition of dead organic matter. HS is present in most freshwaters at concentrations ranging from 0.5 to 50mg L(-1). Organic carbon can represent 20% dry weight of sediments. Recently, the interaction of dissolved HS with the aryl hydrocarbon receptor (AhR) has been demonstrated. The AhR is a cytosolic receptor to which persistent or...

the lack of variation in antifungal drugs, and the misuse or inappropriate use usually causes resistant strains of the yeast in human’s normal flora. unfortunately, a large number of candida infection cases in immunosuppressed patients with insufficient treatment eventually can cause patient's death. the aim of this study was to evaluate the in vitro conventional antifungal azole compounds with...