Abstract   Background: Irregular Working hours, including night work and shift work, have been   found to be associated with alteration in various levels of biochemical factors. And some studies have showed association between shift work and blood biochemical disturbances in blood. In this epidemiological study we investigated, whether regular schedule of working hours can minimize the associ...

Biochemical markers are measurable responses to the exposure of an organism to xenobiotics as well as very suitable biosensors of aquatic pollutants. Aquatic pollution can easily be detected through biomarkers, as enzymes provide one of the most reliable means of assessing the degree of exposure of animals to pollutants. Some of the biochemical alteration occurring in the body gives the first i...

The Leishmania major aquaglyceroporin, LmAQP1, is responsible for the transport of antimonite [Sb(III)], an activated form of Pentostam or Glucantime. Downregulation of LmAQP1 provides resistance to trivalent antimony compounds and increased expression of LmAQP1 in drug-resistant parasites can reverse the resistance. Besides metalloid transport, LmAQP1 is also permeable to water, glycerol, meth...

Abstract Background The fruits of Xylopia aethiopica and seeds leaves Piper guineense are commonly used as spices. Due to their wide use in nutrition traditional medicine, there is need examine the biochemical histological effects ethanolic extracts on liver kidney function male albino rats . test animals (groups 2, 3 4) received 100 mg/kg each corresponding extract for 21 days. Group 1 served ...

Late onset is a common hallmark character of numerous disorders including human neurodegenerative maladies such as Huntington's, Parkinson's and Alzheimer's diseases. Why these diseases manifest in aged individuals and why distinct disorders share strikingly similar emergence patterns were until recently unsolved enigmas. During the past decade, invertebrate-based studies indicated that the ins...

Chromatin regulation is essential to regulate genes and genome activities. In plants, the alteration of histone modification and DNA methylation are coordinated with changes in the expression of stress-responsive genes to adapt to environmental changes. Several chromatin regulators have been shown to be involved in the regulation of stress-responsive gene networks under abiotic stress condition...

A severe mitochondrial protein synthesis defect in myoblasts from a patient with mitochondrial myopathy was transferred with myoblast mitochondria into two genetically unrelated mitochondrial DNA (mtDNA)-less human cell lines, pointing to an mtDNA alteration as being responsible and sufficient for causing the disease. The transfer of the defect correlated with marked deficiencies in respiration...