Multicellular spheroids are important tools for studying tissue and cancer physiology in 3D frequently used engineering as assembling units biofabrication. While the main power of spheroid model is mimicking physical-chemical gradients at microscale, real physiological environment (including dynamics metabolic activity, oxygenation, cell death, proliferation) inside generally ignored. At same t...

Nanobiomaterials play an important role in nanobiotechnology and have made a great contribution to biomedical research and healthcare. Recent progress in nanobiomaterials has increased demand for multidisciplinary approaches from physical, biological and engineering sciences. Solid freeform fabrication (SFF) technologies are based on layer-by-layer deposition of materials which bring about new ...

Biofabrication In article number 2101309, Norbert Radacsi and co-workers show that the combination of electrospinning with 3D printing can create scaffolds suitable for cell growth. The electrospun nanofibers help to attract cells due their extracellular matrix-like structure, while 3D-printed parts serve as macroscopic structure material.

Melt electrowriting (MEW) is an electrohydrodynamic process capable of producing organized patterns micrometer-scale polymer fibers. Integrating MEW with other additive manufacturing technologies, such as extrusion-printing or bioprinting, offers tantalizing possibilities for multi-scale biofabrication anatomically shaped scaffolds. However, introducing 3D structures onto the conventionally fla...