نتایج جستجو برای: biomarker validation

تعداد نتایج: 227799  

Journal: :Journal of proteome research 2007
Remi Lemaire Sonia Ait Menguellet Jonathan Stauber Valerie Marchaudon Jean-Philippe Lucot Pierre Collinet Marie-Odile Farine Denis Vinatier Robert Day Patrick Ducoroy Michel Salzet Isabelle Fournier

MALDI imaging mass spectrometry represents a new analytical tool to directly provide the spatial distribution and relative abundance of proteins in tissue. Twenty-five ovary carcinomas (stages III and IV) and 23 benign ovaries were directly analyzed using MALDI-TOF MS. The biomarker with the major prevalence (80%) has been fully identified using MALDI MS and nanoESI MS and MS/MS after separatio...

2010
Stephen F Kingsmore

COMMENT ON Schwarz et al. Validation of a Blood-Based Laboratory Test to Aid in the Confirmation of a Diagnosis of Schizophrenia. Biomarker Insights. 2010:5 39-47 doi:10.4137/BMI.S4877.

Journal: :Drug discovery today 2011
Michael Nohaile

As drug discovery and translational scientists think about using stratification with biomarkers to improve the chances of getting medicines to patients, several areas of expertise need to be considered. These include analytical validation, clinical validation, regulatory affairs and intellectual property. Getting the right input from the right expert at the right time can make or break an effor...

Journal: :The Journal of pediatrics 2014
Karl G Sylvester Xuefeng B Ling Gigi Yuen-Gee Liu Zachary J Kastenberg Jun Ji Zhongkai Hu Shuaibin Wu Sihua Peng Fizan Abdullah Mary L Brandt Richard A Ehrenkranz Mary Catherine Harris Timothy C Lee B Joyce Simpson Corinna Bowers R Lawrence Moss

OBJECTIVES To test the hypothesis that an exploratory proteomics analysis of urine proteins with subsequent development of validated urine biomarker panels would produce molecular classifiers for both the diagnosis and prognosis of infants with necrotizing enterocolitis (NEC). STUDY DESIGN Urine samples were collected from 119 premature infants (85 NEC, 17 sepsis, 17 control) at the time of i...

Journal: :Clinical chemistry 2012
Rui Liu Xi Chen Yiqi Du Weiyan Yao Lin Shen Cheng Wang Zhibin Hu Rui Zhuang Guang Ning Chunni Zhang Yaozong Yuan Zhaoshen Li Ke Zen Yi Ba Chen-Yu Zhang

BACKGROUND Detection of pancreatic cancer (PaC), particularly at early stages, remains a great challenge owing to lack of specific biomarkers. We sought to identify a PaC-specific serum microRNA (miRNA) expression profile and test its specificity and sensitivity as a biomarker in the diagnosis and prognosis of PaC. METHODS We obtained serum samples from 197 PaC cases and 158 age- and sex-matc...

2015
Victoria M. Benson Fabien Campagne

Biological data analysis is frequently performed with command line software. While this practice provides considerable flexibility for computationally savy individuals, such as investigators trained in bioinformatics, this also creates a barrier to the widespread use of data analysis software by investigators trained as biologists and/or clinicians. Workflow systems such as Galaxy and Taverna h...

2016
Dominik Buschmann Anna Haberberger Benedikt Kirchner Melanie Spornraft Irmgard Riedmaier Gustav Schelling Michael W Pfaffl

Small RNA-Seq has emerged as a powerful tool in transcriptomics, gene expression profiling and biomarker discovery. Sequencing cell-free nucleic acids, particularly microRNA (miRNA), from liquid biopsies additionally provides exciting possibilities for molecular diagnostics, and might help establish disease-specific biomarker signatures. The complexity of the small RNA-Seq workflow, however, be...

Journal: :Journal of the National Cancer Institute 2007
Wenyu Jiang Boris Freidlin Richard Simon

BACKGROUND Many molecularly targeted anticancer agents entering the definitive stage of clinical development benefit only a subset of treated patients. This may lead to missing effective agents by the traditional broad-eligibility randomized trials due to the dilution of the overall treatment effect. We propose a statistically rigorous biomarker-adaptive threshold phase III design for settings ...

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