Corticosteroids are extensively used in pediatrics, yet the burden of side effects is significant. Availability of a simple, fast, and reliable biochemical read out of steroidal drug pharmacodynamics could enable a rapid and objective assessment of safety and efficacy of corticosteroids and aid development of corticosteroid replacement drugs. To identify potential corticosteroid responsive biom...

Saliva as a biological fluid has growing interest as a diagnostic tool over the past decade. Saliva contain a wide spectrum of proteins/peptides, nucleic acids, electrolytes, and hormones that originate from multiple local and systemic sources. In our earlier investigation some of salivary biomarkers in oral cancer patients found to have significant correlation with pathogenesis of oral squamou...

Recent advances in social science surveys include collection of biological samples. Although biomarkers offer a large potential for social science and economic research, they impose a number of statistical challenges, often being distributed asymmetrically with heavy tails. Using data from the UK Household Panel Survey (UKHLS), we illustrate the comparative performance of a set of flexible para...

Information regarding metabolic profile in different physiological periods of ewes can assist veterinarians to monitor the herd health and productive performance. Furthermore, the relationships among the metabolic parameters can be used to detect the effect of each parameter on another one. Five clinically healthy adult Ghezel ewes were selected at 4 weeks before parturition and evaluated at 4 ...

conclusions the mathematical meaning of the two insulin-related biomarkers examined was the same, and the odds ratios of the two biomarkers were almost the same after adjustments for other independent variables. objectives a one-year follow-up study was conducted to determine the ability of the insulin-related biomarkers to predict the risk of mets development. patients and methods a total of 2...

bladder cancer is the fifth most common cancer with significant morbidity and mortality. recently, numerous studies demonstrated that micrornas are emerging as diagnostic biomarkers for bladder cancer. specific mirna profiles have been identified for several samples from patients with bladder cancer. micrornas are noncoding rna molecules of approximately 23 nucleotides that play important roles...

abstract aim and background: studying the role of background causes and biomarkers on early onset cardiovascular diseases' incidence as one important issue is need for prevention of these diseases. the purpose of this study was to identify the role of background factors and biomarkers for early onset cardiovascular diseases' incidence. methods and materials: in a descriptive study with cross-se...

University Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH 5001 Aarau, Switzerland Abstract Introduction The use of an accurate and well-validated triage system in the emergency department is pivotal for early risk stratification of medical patients. For this purpose different clinical scores, such as the Manchester Triage Score, are widely propagated. Prognostic blood bio...

CVD (cardiovascular disease) is the leading cause of death for women. Considerable progress has been made in both our understanding of the complexities governing menopausal hormone therapy and our understanding of the cellular and molecular mechanisms underlying hormone and hormone receptor function. Understanding the interplay of atherosclerosis and sex steroid hormones and their cognate recep...