iv Overall, the results presented in this thesis contribute to the solution of the “electronic coupling problem”, arising when interfacing biomolecules with electronics and limiting the performance of bioelectrocatalytic systems in practical applications. The developed methods to facilitate electron transfer will hopefully promote future biosensing devices and biofuel cells. I believe that the ...

Introduction This chapter looks at technologies of biosensing and techniques of sonification that invoke physicalization of sound to create a sense of intimacy in musical performance and gallery exhibition. By comparing the dynamic across stage and gallery settings, we will see how the corporeal activation of sound can become a key not just to decode experimental performance, but as an entry po...

Cavity ring-down spectroscopy (CRDS) is an established technique for gases sensing that is newly emerging in the field of optical biosensing. This approach measures changes in the rate of decay of light injected into an optical resonator and relates them to optical loss along its length. This principle has recently been adapted for use in liquids, providing a highly sensitive method for quantit...

Biosensing technologies promise to improve Mycobacterium tuberculosis (M. tuberculosis) detection and management in clinical diagnosis, food analysis, bioprocess, and environmental monitoring. A variety of portable, rapid, and sensitive biosensors with immediate "on-the-spot" interpretation have been developed for M. tuberculosis detection based on different biological elements recognition syst...

The increasing availability of semiconductor-based nanostructures with novel and unique properties has sparked widespread interest in their use in the field of biosensing. The precise control over the size, shape and composition of these nanostructures leads to the accurate control of their physico-chemical properties and overall behavior. Furthermore, modifications can be made to the nanostruc...

Growing demand for developing ultrasensitive electrochemical bioassays has led to the design of numerous signal amplification strategies. In this context, carbon-based nanomaterials have been demonstrated to be excellent tags for greatly amplifying the transduction of recognition events and simplifying the protocols used in electrochemical biosensing. This relevant role is due to the carbon-nan...

Carbon nanotubes have been attracting a lot of interest as electron transfer mediators to enhance electrochemical biosensing. The main reason behind this is usually recognized in terms of augmented electrochemical active surface area. The aim of this paper is to review other phenomena that occur at the electrochemical interface. Three distinct features of these phenomena mainly appear in electr...

The signal-to-noise ratio (SNR) for real-time biosensing with liquid-gated carbon nanotube transistors is crucial for exploring the limits of their sensitivity, but has not been studied thus far. Although biosensing is often performed at high transconductance where the device displays the largest gate response, here we show that the maximum SNR is actually obtained when the device is operated i...

Microfluidics-based biochips are soon expected to revolutionize biosensing, clinical diagnostics and drug discovery. Robust off-line and on-line test techniques are required to ensure system dependability as these biochips are deployed for safety-critical applications. Due to the underlying mixed-technology and mixed-energy domains, biochips exhibit unique failure mechanisms and defects. We fir...

Biosensors are nowadays ubiquitous in biomedical diagnosis as well as a wide range of other areas such as point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery, forensics and biomedical research. A wide range of techniques can be used for the development of biosensors. Their coupling with high-affinity biomolecules allows the sensi...