BACKGROUND/OBJECTIVES Current laser therapy of port wine stain (PWS) birthmarks with a single laser pulse (SLP) does not produce complete lesion removal in the majority of patients. To improve PWS therapeutic efficacy, we evaluated the performance of an approach based on multiple laser pulses (MLP) to enhance blood vessel photocoagulation. STUDY DESIGN The hamster dorsal window chamber model ...

I applaud Qin et al. for their publication, “Photodynamic therapy of port wine stains – a report of 238 cases”1. Such extensive experience with photodynamic therapy (PDT) for port wine stains (PWS) is impressive and I believe, unequaled in the Western world. In the United States and Europe, pulsed lasers and light sources, especially the pulsed dye laser (PDL; wavelengths = 585 or 595 nm) are t...

Abstract A full-term infant was noted to have a large, macular, pale-pink vascular birthmark across the left side of chest, extending upper arm. Three smaller irregular birthmarks on elbow, thigh and flank were noted, as an enlarged He had oxygen dependency shortly after birth for which he required admission neonatal unit. detailed history revealed that his father, paternal grandmother aunt sim...

BACKGROUND AND OBJECTIVES Complete blanching of port wine stain (PWS) birthmarks after laser therapy is rarely achieved for most patients. We postulate that the low therapeutic efficacy or treatment failure is caused by regeneration and revascularization of photocoagulated blood vessels due to angiogenesis associated with the skin's normal wound healing response. Rapamycin (RPM), an antiangioge...

the exclusion of the general surgery of the deep structures of the foot or face. In connection with the face are considered birthmarks, congenital growths, iuevi, abscesses, ulcerations, parasitic diseases, surface tumours, dental abscess, incised wounds, fractures and dislocations, burns and scalds, plastic surgery, deformities of the eyelid and eyeball, deformities of neurotic origin, &c. In ...