The aryl hydantoin 1 (Ro 13-3978) was identified in the early 1980s as a promising antischistosomal lead compound. However, this series of aryl hydantoins produced antiandrogenic side effects in the host, a not unexpected outcome given their close structural similarity to the antiandrogenic drug nilutamide. Building on the known SAR of this compound series, we now describe a number of analogs o...

Based on the 40-year follow-up of the Framingham Heart Study (FHS), we used logistic regression models to demonstrate that different designs of an observational study may lead to different results about the association between BMI and all-cause mortality. We also used dynamic survival models to capture the time-varying relationships between BMI and mortality in FHS. The results consistently sho...

A series of latonduine derivatives, namely 11-nitro-indolo[2,3-d]benzazepine-7-(1-amino-hydantoin) (B), triazole-fused indolo[2,3-d]benzazepine-based Schiff bases HL1 and HL2 metal complexes [M(p-cymene)(HL1)Cl]Cl, where M = Ru (1), Os (2), [Cu(HL2)Cl2] (3) were synthesized characterized by spectroscopic techniques (UV–vis, 1H, 13C, 15N–1H HSQC NMR) ESI mass spectrometry. The molecular structur...

Herein, we report the synthesis of platinum(II) complex bearing 3?-aminothiocyclohexanespiro-5?-hydantoin as ligand. The was characterized by IR, NMR spectral analyses, elemental analyses and density functional theory (DFT) calculations. Cytotoxicity inhibitory potential on xanthine oxidase (XO) were evaluated performed docking cytotoxic activities (1), its Pt(II) (2), thiocyclohexanespiro-5?-h...

the reaction of bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione (curcumin) and two novel ligands of bis[4-tetrabenzylglucose-3-methoxyphenyl]-1,6-heptadiene-3,5-dione (bis(tetrabenzylglucose)curcumin) (btbgc) and bis[4-tetraacetylglucose-3-methoxyphenyl]-1,6-heptadiene-3,5-dione (bis(tetraacetylglucose)curcumin) (btagc) with vanadium in methanol, in a 2:1 molar ratio, which yield the co...