The major neutralizing epitope (MNE) for the Epstein-Barr virus (EBV) is present on its envelope glycoprotein gp350/220 (hereafter referred to as gp350) in close proximity to the virus-receptor (CR2) binding site and is recognized by the neutralizing murine monoclonal antibody (mAb) 72A1. We studied the reactivities of 72A1 and another anti-gp350 mAb 2L10 (which does not neutralize EBV) with gp...

Background: Transcutaneous CO2 monitoring presents an opportunity for Paco2 measurement in the presence of inaccurate or absence end-tidal (ETCO2) monitoring. Whilst it is regularly used neonates to prevent frequent blood sampling, seldom adult anaesthesia intensive care medicine. We demonstrate three clinical examples using transcutaneous (TCM) where gas sampling ETCO2 was either unavailable c...

Jennifer Gallagher, Kisurb Choe, and Michael Snyder are missing from the author list. Please view the correct author order, affiliations, and citation here: Giltae Song , Benjamin J. A. Dickins , Janos Demeter , Stacia Engel , Jennifer Gallagher , Kisurb Choe , Barbara Dunn , Michael Snyder , J. Michael Cherry 1 1 Department of Genetics, Stanford University School of Medicine, Stanford, Califor...

The cytotoxicity and the antivirus activity of Pd(II) and Pt(II) complexes with pyridine-2-carbaldehyde thiosemicarbazone (HFoTsc) against HSV replication were evaluated on four HSV strains-two wt strains Victoria (HSV-1) and BJA (HSV-2) and two ACV(R) mutants with different tk gene mutations R-100 (TK(A), HSV-1) and PU (TK(N), HSV-2). The experiments were performed on continuous MDBK cells and...

Monkey B-lymphotropic papovavirus (LPV) DNA present as free copies in LPV-transformed hamster embryo cells was molecularly cloned in Escherichia coli. Twenty-two of 24 cloned DNAs were 4.9 kilobases long and shorter than the wild-type LPV DNA (5.1 kilobases). The shorter DNA was nondefective and generated infectious virus (designated LPV-76) upon transfection of human B-lymphoblastoid BJA-B cel...

Severe persistent post-surgical pain (PPP) affects 2–10% of adults undergoing surgery, corresponding to at least 140 000 patients per year presenting with disabling pain in the UK. Surgery is indeed pivotal in the treatment of a number of serious diseases, and, while the overall benefits to patients are unquestionable, the quest of identifying improved techniques of preventing or mitigating sev...