IN THE LATE 1940's Duff and McMillan' 2 made the remarkable observation that alloxan-diabetic rabbits developed equal or higher blood cholesterol levels, but markedly less atherosclerosis, than did nondiabetic rabbits fed an equivalent high-cholesterol diet. From the excessive visible lipemia characteristic of the alloxan-diabetic rabbits in this experiment, Duff and McMillan surmised that the ...

In a previous paper (1) we reported that, when livers from rats fed diets containing 2% cholesterol were perfused with whole blood from normal rats, the concentration of cholesterol and triglyceride in the perfusate increased significantly. These lipids were present almost entirely in the lipoproteins of density (d) < 1.019. In the present investigations the transfer of lipids from the liver in...

Abstract Objective The aim of this study was to investigate the potential association rs11206510 in PCSK9 gene with coronary artery disease (CAD) and myocardial infarction (MI) Bulgarians. Materials Methods current analysis included 261 patients angiographically documented CAD (153 MI 108 without MI) 496 population – based controls. Genomic DNA extracted from venous blood samples. selected poly...

BACKGROUND It remains undetermined whether triglyceride-rich lipoproteins are an independent risk factor for atherosclerosis. METHODS AND RESULTS The correlation of responses of coronary arterial diameter (quantitative coronary angiography) and coronary blood flow (intracoronary flow wire technique) to intracoronary infusion of acetylcholine (10 and 50 microg/min) with coronary risk factors i...

The possible role of human plasma lipoproteins as car riers in the transport of the carcinogen, benzo(a)pyrene, was assessed in in vitro studies. [14C]Benzo(a)pyrene was incubated in whole human blood, plasma, or isolated lipo protein fractions. Benzo(a)pyrene d istribution between plasma and red blood cells was estimated following sedi mentation of red blood cells. Benzo(a)pyrene distribution ...

introduction: the fetus needs a considerable amount of cholesterol for the development of tissues and organs.  studies have suggested that genetic and environmental factors influence the composition of cord blood lipoproteins.  in this study, we aim to assess the effect of gestational age, sex and birth weight on the cord blood lipoproteins. methods: we collected umbilical cord blood samples fr...

background: the present work was planned to evaluate the antihyperglycemic, lipid‑lowering, and antioxidant effect of lactobacillus casei and bifidobacterium bifidum in streptozotocin (stz)‑induced diabetic rats. methods: single daily dose of 1 × 107 cfu/ml of l. casei and b. bifidum alone and in combination of both was given to wistar rats orally by gavaging for 28 days. glucose tolerance test...

This study was designed to assess changes in diet and serum lipoproteins in shift workers. Twelve shift workers and 13 day workers were examined before employment and after six months at work. Total cholesterol and serum triglycerides did not change significantly. In both groups a decrease in systolic blood pressure was observed. The ratio between apoB and apoA-1 lipoproteins increased by 18% i...

Structural lipids, primarily phospholipids and sterols, as well as energy-storage lipids such as triacylglycerols are insoluble in water. In the aqueous fluids of animals, they are carried as lipoproteins, complexes of lipids bound to polypeptides. These watersoluble lipoproteins can be separated into different classes, depending upon their hydrated densities. These classes include very low den...