Manganese (Mn) is a required element and a metabolic byproduct of the contrast agent mangafodipir trisodium (MnDPDP). The Mn released from MnDPDP is initially sequestered by the liver for first-pass elimination, which allows an enhanced contrast for diagnostic imaging. The administration of intravenous Mn impacts its homeostatic balance in the human body and can lead to toxicity. Human Mn defic...

PURPOSE A retrospective study of radiation-induced apoptosis in CD4 and CD8 T-lymphocytes, from 12 cancer patients who displayed enhanced toxicity to radiation therapy and 9 ataxia telangiectasia patients, was performed to test for altered response compared to healthy blood-donors and normal cancer patients. METHODS AND MATERIALS Three milliliters of heparinized blood from each donor was sent...

OBJECTIVE Based on animal studies and anecdotal case reports, high-dose therapy and autologous blood stem cell rescue have been proposed as an experimental treatment for severe, refractory rheumatoid arthritis (RA). This study aimed to establish the toxicity of this treatment and obtain preliminary efficacy data upon which to base future clinical trials. METHODS Two cohorts of 4 patients who ...

Cancer risk management involves obliterating excess concentration of cancer causing trace elements by the natural immune system and hence intake of nutritious diet is of paramount importance. Human diet should consist of essential macronutrients that have to be consumed in large quantities and trace elements are to be consumed in very little amount. As some of these trace elements are causative...

Background and Aims: Mercury, with its oxidative activity, causes damage to the antioxidant enzymes thus resulting in physiological disorders. Sodium selenide is an antioxidant that protects antioxidant enzymes. The aim of this study was to investigate the protective effect of sodium selenide on renal toxicity induced by mercuric chloride in rats. Materials and Methods: Animals were divided in...

background: the activity and toxicity of etoposide in women with recurrent ovarian cancer was evaluated in a case series of women with recurrent ovarian cancer who had measurable disease, methods: all patients had plior platinum-based chemotherapy and developed progressive disease, etoposide was given as 50mg/day for 21 days every 4 weeks until progression of disease or prohibitive toxicity, be...

the study monitored the toxicity of environmentally relevant concentration of pesticides and metals in zebra fish danio rerio. zebra fish were exposed to environmentally relevant concentration of pesticides and metals for a period of 14 days. the individual and the combined toxicity of pesticides and metals were evaluated. the pesticides and metals treated groups showed histopathological altera...

Cinnamic acid analogs are natural phenolic compounds that have a wide range of biological and therapeutic activities. The present work aimed to predict, through in silico methodologies, the oral bioavailability pharmacokinetic toxicological analyzes for four cinnamic analogues (caffeic acid, ferulic p-coumaric synaptic acid). study revealed good bioavailability, favorable parameters. Virtual Sc...