s and posters .............................................................................................................. 184 Supplementary files ................................................................................................................. 189 Abstract / Résumé.........................................................................................................211 Résu...

CONTEXT Identifying relationships among anatomical structures is key in diagnosing somatic dysfunction. Ultrasonography can be used to visualize anatomical structures, identify sacroiliac landmarks, and validate anatomical findings and measurements in relation to somatic dysfunction. As part of the osteopathic manipulative medicine course at A.T. Still University-Kirksville College of Osteopath...

We previously investigated the potential of targeted radiotherapy using a bismuth-213 ((213)Bi)-labeled anti-CD45 antibody to replace total body irradiation as conditioning for hematopoietic cell transplantation in a canine model. Although this approach allowed sustained marrow engraftment, limited availability, high cost, and short half-life of (213)Bi induced us to investigate an alternative ...

Peritoneal metastasis of gastric cancer (PMGC) is incurable and thus has an extremely poor prognosis. We have found, however, that locoregionally administered trastuzumab armed with astatine-211 (211 At-trastuzumab) is effective against human epidermal growth factor receptor 2 (HER2)-positive PMGC in a xenograft mouse model. We first observed that 211 At-trastuzumab can specifically bind and ef...

introduction: to compare outcomes of retrograde intrarenal surgery (rirs) with extracorporeal shock wave lithotripsy (eswl) as treatment of choice. methods: a total number of 46 patients with renal pelvic stones 10-20 mm and body mass index (bmi) >30 randomized in two groups underwent rirs and eswl from 2011 to 2014 and followed for 3 months. results: the patients mean ± sd age was 36.1 ± 13.1 ...

The complex molecular mechanisms involved in the development and progression of cutaneous malignant melanoma remain incompletely understood. Small 22-nucleotide microRNAs (miRNAs), which are becoming increasingly known to be associated with tumorigenesis, may now offer insight into the aggressively invasive behavior of melanoma. This new class of small RNAs targets mRNA turnover and translation...

Angiopoietin‑1 (ANG‑1), a ligand of the endothelial cell‑specific TIE2 surface receptor, acts in a complementary and coordinated manner with vascular endothelial growth factor during the process of angiogenesis. ANG‑1 can be used as a clinically informative biomarker of disease severity and outcome in severe sepsis. The epithelium‑specific Ets transcription factor 1 can activate ANG‑1 transcrip...

Dexanabinol, HU-211, a synthetic cannabinoid devoid of psychotropic effects, improves neurological outcome in models of brain trauma, ischemia and meningitis. Recently, HU-211 was found to inhibit brain tumor necrosis factor (TNFalpha) production after head injury. In the present study, we demonstrate the ability of HU-211 to suppress TNFalpha production and to rescue mice and rats from endotox...

Retroviral vectors were modified to contain packaging (psi) signals of varying lengths (nucleotides 211-355, 211-565, or 211-1039 of MoMuLV RNA) between the U3-r and U5 sequences of their 5' long terminal repeat (LTR). For the vector MoTN-PR3, containing the full length 211-1039 nucleotide-long psi signal within the 5' LTR, replication, integration, and packaging were almost as efficient as for...