The size of conformational ensembles required for regular coverage of the conformational space of druglike molecules was examined. Using the conformer generation program Omega, the number of regularly distributed conformers (NRC) of flexible compounds was determined as a function of the root-mean-square deviation (RMSD) resolution of coverage. A regression equation was developed predicting the ...

A set of perception experiments, using reiterant speech, were designed to carry out a diagnostic of the segmentation / hierarchisation linguistic function of prosody. The prosodic parameters of F0, syllabic duration and intensity of the stimuli used during this experiment were extracted. Several dissimilarity measures (Correlation, root-mean-square distance and mutual information) were used to ...

Authors investigated the effects of different jaws relations on body posture in a sample of 95 subjects. All subjects underwent a posturometric and stabilometric analysis using a computerized footboard. Tests were performed in three mandibular positions: centric occlusion, rest position and myocentric position, respectively determined by teeth engagement, joints position, and muscles contractio...

Introduction: To study the effects of exercise, how important it is to choose a posture? We aimed to characterize the possible impact of different body positions on cardiovascular parameters during and after sustained isometric handgrip (IHG) exercise. Materials and Methods: Cross sectional study was carried out in 33 young adult males (mean age: 19.21±1.083 years). We recorded Bloo...

Whole-body PET scanning for an oncology study produces a large number of transaxial images by data acquisition over multiple bed positions. The sagittal and coronal reformatted images are often used for better understanding of radioisotope distribution. We reduced the number of PET images by calculating projection images and evaluated the merit of additional data processing for the visualizatio...

We consider the stability of equilibrium positions in the planar circular restricted four-body problem formulated on the basis of Lagrange’s triangular solution of the three-body problem. The stability problem is solved in a strict nonlinear formulation on the basis of Arnold–Moser and Markeev theorems. Peculiar properties of the Hamiltonian normalization are discussed, and the influence of the...

The aim of the study was to elucidate combined effects of water immersion (WI) and changing body positions on human cardiorespiratory (CR) function in regular swimming pool conditions. Twelve young healthy volunteers (6 females, 6 males) adopted a series of eight 4-min resting body positions on dry land and during WI. CR and gas exchange parameters were measured breath-by-breath by a telemetric...