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In oral cancers, cytoplasmic BAG-1 overexpression is a marker of poor prognosis. BAG-1 regulates cellular growth, differentiation and survival through interactions with diverse proteins, including the vitamin D receptor (VDR), a key regulator of keratinocyte growth and differentiation. BAG-1 is expressed ubiquitously in human cells as three major isoforms of 50 kDa (BAG-1L), 46 kDa (BAG-1M) and...

purpose the objectives of this study include: (1) determination of the attenuation of strike acceleration that tae kwon do sparring safety pads provide from kicks from olympic style tkd fighters, (2) the sex and weight differentiation in acceleration achieved within the thorax model with the roundhouse kicks. methods this prospective, observational study utilized 15 olympic style fighters from ...

High Neotropical mountains are among the most threatened ecosystems by climate change and this problem could be accentuated in cities where temperatures are higher. However, there are few data of long-term avifaunal changes in Neotropical cities, and the potential impact of climate change has yet to be addressed. Using data from 26 years of Audubon’s Christmas Bird Counts (CBCs) in the Bogotá a...

Part of the cellular and physiological functions of BAG-1 (Bcl-2-associated athanogene 1) has been ascribed to the ability of this hsp70 (heat-shock protein 70) co-chaperone to regulate steroid receptor activity. BAG-1 has been reported to inhibit the GR (glucocorticoid receptor) and stimulate the androgen receptor, but to leave the activity of the MR (mineralocorticoid receptor) unchanged. Giv...

purpose: to report a case of capsular bag distension syndrome (cbds) with solid material presenting eight years after cataract surgery. case report: a 58-years-old female who underwent an uneventful clear-cornea phacoemulsification with in-the-bag intraocular lens (iol) implantation in the right eye, presented with a chief complaint of blurred vision (va: 20/200) and cobweb like matter appearin...

BACKGROUND AND OBJECTIVE: It has been suggested that probiotics may decrease infant mortality and nosocomial infections because of their ability to suppress colonization and translocation of bacterial pathogens in the gastrointestinal tract. We designed a large doubleblinded placebo-controlled trial using Lactobacillus reuteri to test this hypothesis in preterm infants. METHODS: Eligible infant...

BAG-1 is a multifunctional protein that blocks apoptosis and interacts with several types of proteins, including Bcl-2 family proteins, the kinase Raf-1, certain tyrosine kinase growth factor receptors, and steroid hor mone receptors, possibly by virtue of its ability to regulate the Hsp70/ Hsc70 family of molecular chaperones. Two major forms of the human and mouse BAG-1 proteins were detected...