BACKGROUND This study aims to investigate the biocompatibility and in vivo osteogenic capability of the novel bone tissue engineering scaffold apatite-wollastonite-magnetic glass ceramic/chitosan (A-W-MGC/CS). METHODS Rabbit bone marrow stromal cells (BMSCs) were transfected with adenovirus-human bone morphogenetic protein-2-green fluorescent protein (Ad-hBMP2-GFP). The transfected BMSCs were...

In the last years, several methods have been used to enhance bone repair and new bone formation. Numerous researches have been focused on possibilities of healing bone defect by using biomaterial implants. Clay cement may represent an important bone substitute and could be used for the treatment of multiple fractures and after bone tumor resection. The aim of this study is to investigate biocom...

background and aims. complete and predictable regeneration of tissue lost as a result of infection or trauma is the ultimate goal of periodontal therapy. various graft materials have been successfully used in the treatment of intrabony defects. the purpose of this study was to evaluate the use of a decalcified freeze-dried bone allograft (cerabone) with the autogenous bone graft as a gold stand...

Fracture and bone segment loss are major clinical problems in birds. Achieving bone formation and clinical union in a fracture case is important for the survival of the bird. To evaluate the efficacy of bone grafts for defect healing in birds, 2 different bone grafts were investigated in the healing of a bone defect in 24 healthy pigeons ( Columba livia ). In each bird, a 1-cm critical size def...

The aim of the study was to assess quantitatively the amount of new bone formed in the early stages of healing of intramembranous and endochondral autogenous bone grafts so as to gain further insight into their integration with host bone. Eighteen critical size defects were created in the parietal bone of nine New Zealand White rabbits. In the experimental group (five rabbits), each rabbit was ...

Using tissue engineering technology research to develop organized artificial bone, then repair bone defect. This work aims to investigate the role of semisynthetic extracellular matrix-like hydrogel (sECMH) containing hepatocyte growth factor (HGF) on repair of femoral neck defect in rabbits. 18 New Zealand rabbits were used in this study. According to autologous paired comparison method, the l...

INTRODUCTION Tibia fracture caused by high velocity missiles is mostly comminuted and followed by bone defect which makes their healing process extremely difficult and prone to numerous complications. CASE OUTLINE A 34-year-old male was wounded at close range by a semi-automatic gun missile. He was wounded in the distal area of the left tibia and suffered a massive defect of the bone and soft...

PURPOSE To study were to reproduce an alveolar bone defect model in Wistar rats to be used for testing the efficacy of stem cell therapies. Additionally, we also aimed to determine the osteogenesis process of this osseous defect in the 1 month period post-surgery. METHODS The animals were randomly divided into two groups of 7 animals each. A gingivobuccal incision was made, and a bone defect ...

Reconstruction of a maxillary dentoalveolar defect and closure of a wide oronasal fistula in a patient with a traumatic injury are challenging for both orthodontists and surgeons. A conventional bone graft is used to fill the alveolar bone defect, to restore continuity between bony segments, and to provide bony support for tooth eruption adjacent to the defect or for orthodontic tooth movement ...