isolated skeletal metastasis to the bony calvarium is extremely rare in patients with squamous cell carcinoma of the uterine cervix. we describe the clinical and imaging findings in a case of squamous cell carcinoma of the uterine cervix with metastases to the bony calvarium as the sole site of metastasis. the patient was a 65-year-old woman with squamous cell carcinoma of the uterine cervix, f...

PURPOSE Bone metastasis from stomach cancer occurs only rarely and it is known to have a very poor prognosis. This study examined the clinical characteristics and prognosis of patients who were diagnosed with stomach cancer and bone metastasis. MATERIALS AND METHODS The subjects were 19 patients who were diagnosed with stomach cancer at Hanyang University Medical Center from June 1992 to Augu...

OBJECTIVE The aim of the study was to establish a predictive model of survival period after bone metastasis from cervical cancer. METHODS A total of 54 patients with bone metastasis from cervical cancer were included in the study. Data at the time of bone metastasis diagnosis, which included presence of extraskeletal metastasis, performance status, history of any previous radiation or chemoth...

Early treatment of patients with malignant disease and liver or bone metastasis may increase their survival time. We have used the activity patterns of liver and bone isoenzymes of alkaline phosphatase (ALP), separated by agarose gel electrophoresis, to detect early metastasis. We studied ALP isoenzyme patterns in a background population of 101 patients with no evidence of any disease that migh...

BACKGROUND Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatments using powerful anti-resorptive agents are only palliative indicating that factors independent of bone resorption control bone metastasis progression. Autotaxin (ATX/NPP2) is a secreted protein with both oncogenic and pro-metastatic properties. Through its lysosphospholipase D (lyso...

Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. The bony metastasis is incurable and contributes significantly to disease-specific morbidity and mortality. The molecular and cellular mechanisms leading to the development of bone metastasis in prostate cancer remain unclear, but are currently under intensive investigation. In this ...

AIM The early and precise diagnosis and proper palliative treatment of bone metastasis is important for improving the quality of life of cervical cancer patients. The aim of this study was to clarify the clinical features, treatment modalities and prognosis of bone metastasis in cervical cancer patients in Japan. METHODS The medical records of 75 cervical cancer patients with bone metastasis ...

OBJECTIVES BONENAVI, a computer-aided diagnostic system, is used in bone scintigraphy. This system provides the artificial neural network (ANN) and bone scan index (BSI) values. ANN is associated with the possibility of bone metastasis, while BSI is related to the amount of bone metastasis. The degree of uptake on bone scintigraphy can be affected by the type of bone metastasis. Therefore, the ...

Primary angiosarcoma of bone is very rare.It occurs more commonly in middle-age and later life, with a male predominance in the ratio of 2:1. Angiosarcoma of bone has a tendency to involve the long tubular bones, and multifocal involvement is common. Here, we present a case of a 69-yr-old man in Shahid Sadooghi Hospital of Yazd in 2014 that had angiosarcoma of the left tibia. He was treated wit...

Bone is a common site of metastasis in human cancer. A major impediment to understanding the pathogenesis of bone metastasis has been the lack of an appropriate animal model. In this paper, we describe an animal model in which B16 melanoma cells injected in the left cardiac ventricle reproducibly colonize specific sites of the skeletal system of mice. Injection of 10(5) cells resulted in melano...