Gene array analysis has been widely used to identify genes induced during T cell activation. Our studies identified an immediate early gene that is strongly induced in response to IL-2 in mouse T cells which we named cysteineserine-rich nuclear protein-1 (CSRNP-1). The human ortholog was previously identified as an AXIN1 induced gene (AXUD1). The protein does not contain sequence defined domain...

This little brochure will be of interest to all medical practitioners with a large private practice. The author details what books should be kept by a doctor, and how to keep them. He points out how slipshod and unsatisfactory medical book-keeping often is; so that a locum can often hardly understand what has happened previously in the practice, or, when a practice comes to be sold, it is diffi...

Angela N H Creager, Elizabeth Lunbeck and Londa Schiebinger (eds), Feminism in twentieth-century science, technology, and medicine, Women and Culture in Society, University of Chicago Press, 2001, pp. xii, 264, US$65.00 (hardback 0-226-12023-6), US$20.00 (paperback 0-226-12024-4). Myron Echenberg, Black death, white medicine: bubonic plague and the politics of public health in colonial Senegal,...

Louise Hill Curth (ed.), From physick to pharmacology: five hundred years of British drug retailing, Aldershot, Ashgate, 2006, pp. xii, 174, £50.00 (hardback 0-7546-3597-X; 978-07546-3597-0). Allen G Debus, The chemical promise: experiment and mysticism in the chemical philosophy, 1550–1800: selected essays, Sagamore Beach, Science History Publications/ USA, 2006, pp. xxv, 548, $89.95 (hardback...

Background: The need for fast and accurate scoring functions has been driven by the increased use of in silico virtual screening twinned with high-throughput screening as a method to rapidly identify potential candidates in the early stages of drug development. We examine the ability of some the most common scoring functions (GOLD, ChemScore, DOCK, PMF, BLEEP and Consensus) to discriminate corr...