OBJECTIVE Psychotic experiences occur at a much greater prevalence in the population than psychotic disorders. There has been little research to date, however, on genetic risk for this extended psychosis phenotype. We examined whether COMT or BDNF genotypes were associated with psychotic experiences or interacted with childhood trauma in predicting psychotic experiences. METHOD Psychiatric in...

BACKGROUND Evidence of remission from borderline personality disorder (BPD) without specialised treatment is accumulating. AIMS To establish whether specialised treatments are indicated for patients with clinically severe disorder. METHOD The impact of clinical severity on outcomes of a randomised controlled trial of mentalisation-based treatment (MBT) was contrasted with structured clinica...

Objective: Borderline personality disorder is one of the most severe psychiatric disorders. The purpose of this study was to predict distress tolerance, impulsivity and aggression based on emotional dysregulation and reward sensitivity among individuals with borderline personality disorder features. Methods: The statistical population of the present research was undergraduate students of Shahi...

A growing body of literature has revealed that mindfulness-based interventions consistently have positive outcomes, suggesting that increased mindfulness is related to decreases in psychological symptoms and increases in well-being. In a sample of 110 Mount Royal University undergraduate students, we explored the intercorrelations between mindfulness, borderline personality traits, and subjecti...

BACKGROUND The presence of a comorbid borderline personality disorder (BPD) may be associated with an increase of suicidal behaviors in patients with depressive and anxiety disorders. The aim of this study is to examine the role of borderline personality traits on recurrent suicide attempts. METHODS The Netherlands Study on Depression and Anxiety included 1838 respondents with lifetime depres...

BACKGROUND Latent rheumatic heart disease (RHD) occurs in asymptomatic individuals with echocardiographic evidence of RHD and no history of acute rheumatic fever. The natural history of latent RHD is unclear but has important clinical and economic implications about whether these children should receive penicillin prophylaxis or not. We performed a 5-year prospective study of this question. M...

In clinical trials for dietary supplements and functional foods, the study population tends to be a mixture of healthy subjects and those who are not so healthy but are not definitely diseased (called "borderline subjects"). For such heterogeneous populations, the t-test and ANCOVA method often fail to provide the desired treatment efficacy. We propose an alternative approach for the efficacy e...