The six elements commonly known as metalloids are boron, silicon, germanium, arsenic, antimony, and tellurium. Metalloid containing compounds have been used as antiprotozoal drugs. Boron-based drugs, the benzoxaboroles have been exploited as potential treatments for neglected tropical diseases. Arsenic has been used as a medicinal agent and arsphenamine was the main drug used to treat syphilis....

Boron-conjugated 4-anilinoquinazolines were designed and synthesized as inhibitors of EGFR tyrosine kinase with possible covalent bond interactions between the boron atom and the nucleophilic groups of the EGFR kinase domain. Among the compounds synthesized, compounds 6c, 7b, and 7d reduced the EGF-mediated phosphorylation of EGFR tyrosine kinase and its downstream kinases including ERK and Akt...

The Suzuki-Miyaura cross-coupling is one of the most often utilized reactions in the synthesis of pharmaceutical compounds and conjugated materials. In its most common form, the reaction joins two sp(2)-functionalized carbon atoms to make a biaryl or diene/polyene unit. These substructures are widely found in natural products and small molecules and thus the Suzuki-Miyaura cross-coupling has be...

The boronium-carbonium ion continuum was extended to include hypercoordinated onium-carbonium dications and the isoelectronic onium-boronium cation analogs. Structures and (13)C and (11)B NMR chemical shifts of the onium-carbonium dications and the corresponding isoelectronic and isostructural onium-boronium cations were calculated with the ab initio/GIAO-MP2 method. The data show a good linear...

Introduction: Boron neutron capture therapy (BNCT) is a method of cancer treatment and potentially, two borono-L-phenylalanine (BPA) and sodium borocaptate (BSH) are used in BNCT as common boron carriers. Some previous studies have shown that the dose rate is directly related to boron concentration in the tissue. This study aimed to simulate the structure of boron carriers and brain tumor compo...

The effect of valence electron concentration VEC and size of the X element in XMgB14 space group Imma X=Al, C, Si, Ge, Mg, Sc, Ti, V, Zr, Hf, Nb, Ta on stability and elastic properties was studied using ab initio calculations. Generally, icosahedral bonds, present in these compounds, are electron deficient. Based on the Bader charge analysis Bader, Atoms in Molecules: A Quantum Theory Oxford Un...

A synthetic methodology is developed to generate boron rich aromatic small molecules based on benzene and pyrene moieties for the detection of thermal neutrons. The prepared aromatic compounds have a relatively high boron content up to 7.4 wt%, which is important for application in neutron detection as (10)B (20% of natural abundance boron) has a large neutron induced reaction cross-section. Th...

Atomic clusters have intermediate properties between that of individual atoms and bulk solids, which provide fertile ground for the discovery of new molecules and novel chemical bonding. In addition, the study of small clusters can help researchers design better nanosystems with specific physical and chemical properties. From recent experimental and computational studies, we know that small bor...

A regioselective transition metal-catalyzed cycloisomerization reaction of boron-containing alkynyl epoxides toward C2- and C3-borylated furans has been developed. It was found that the copper catalyst as well as the gold catalyst with more basic triflate counterion favor boryl migration toward C3-borylated furans, whereas employment of the cationic gold hexafluoroantimonate affords C2-borylate...

A series of structurally simple yet highly tunable organoboron luminophores was designed and synthesized. The solid-state fluorescence quantum yields exhibit nearly exponential growth by decorating the luminophore with additional sterically demanding substituents. Uniquely, the luminescence of these organoboron dyes can be easily switched on/off by acidic/basic vapors, yielding a solid-state fl...