BACKGROUND Brain size is associated with cognitive ability in adulthood (correlation approximately .3), but few studies have investigated the relationship in normal ageing, particularly beyond age 75 years. With age both brain size and fluid-type intelligence decline, and regional atrophy is often suggested as causing decline in specific cognitive abilities. However, an association between brai...

Introduction: Psoriasis is a systemic autoimmune disease that associated with numerous comorbidities. Objective: This study aimed to compare the prevalence of small vessel cerebrovascular (SVCD) and atrophic brain changes in MRI patients psoriasis normal subjects. Materials Methods: case-control was performed on 27 individuals who were referred dermatology academic center 2019 2020. Basic demog...

OBJECT Intracerebral hemorrhage (ICH) causes brain atrophy and neurological deficits. The mechanisms of brain atrophy after ICH are poorly understood, although recent evidence suggests that some ICH-induced brain injury results from the products of hemoglobin degradation, including iron. In this study the authors examine the role of iron in brain atrophy and neurological deficits following ICH....

Brain volume loss measured with structural MRI is accepted as a pathology marker, e.g., for Alzheimer's disease (AD). Atrophy can be measured with a variety of methods, some of which are longitudinal (measuring atrophy rate, for example, % brain volume change (PBVC), using two or more temporally-separated scans) and others being cross-sectional (measuring atrophy state, for example, brain volum...

BACKGROUND Dual-task walking is believed to be more cognitively demanding than normal walking and alters trunk movement among older adults. However, the possible association between brain atrophy and spatiotemporal gait parameters, particularly during dual-task walking, is poorly understood. In this study, we examined the relationship between dual-task walking and brain atrophy. METHODS One h...

PURPOSE To determine the incidence of brain atrophy and dementia after whole-brain radiotherapy (WBRT) in patients with brain metastases not undergoing surgery. METHODS AND MATERIALS Eligible patients underwent WBRT to 40 Gy in 20 fractions with or without a 10-Gy boost. Brain magnetic resonance imaging or computed tomography and Mini-Mental State Examination (MMSE) were performed before and ...

OBJECTIVES Brain atrophy is a common finding in alcoholics. Several mechanisms may be involved, including ethanol itself, malnutrition, liver failure, and, possibly, ethanol-induced hormone and cytokine changes. The aim of this study was to analyse the relation of brain atrophy-assessed by computerized tomography (CT) scan-and the aforementioned alterations. METHODS Serum insulin-like growth ...

Cerebral small vessel disease is a common condition associated with lacunar stroke, cognitive impairment and significant functional morbidity. White matter hyperintensities and brain atrophy, seen on magnetic resonance imaging, are correlated with increasing disease severity. However, how the two are related remains an open question. To better define the relationship between white matter hyperi...

BACKGROUND Cerebrospinal fluid (CSF) α-synuclein is reduced in synucleinopathies, including dementia with Lewy bodies, and some studies have found increased CSF α-synuclein in Alzheimer's disease (AD). No study has explored effects of CSF α-synuclein on brain atrophy. Here we tested if baseline CSF α-synuclein affects brain atrophy rates and if these effects vary across brain regions, and acros...