Delirium is a frequent complication after surgery with important negative outcomes for affected patients and society. However, it still largely unknown why some have predisposition delirium others not. To increase our understanding of the neural substrate postoperative delirium, we studied association between preoperative brain MRI features occurrence major surgery. A group 413 without dementia...

OBJECTIVES Subjective tinnitus has associated with abnormal brain metabolism and perfusion found in functional imaging studies by fluorodeoxyglucose (FDG) and technetium99m (TC99m). But there is no study evaluating the association of brain metabolism and perfusion abnormalities in a group of these subjects. The aim of this study was to investigate if there is any significant correlation between...

Continuous monitoring of brain perfusion at the bedside in neurointensive care is desirable. Currently used imaging modalities are not suited for frequent monitoring and often require the transport of the patient. Noninvasive near infrared spectroscopy (NIRS) in combination with an injection of a safe dye (indocyanine green, ICG) could serve as a quasicontinuous brain perfusion monitor. In this...

Brain MR perfusion imaging is used to evaluate local perfusion in patients with cerebral vascular disease. Quantitative measurements on the hemodynamic parameters and volume of brain with abnormal perfusion provide an estimation of the severity of the brain perfusion defect. However, quantitative measurements of these focal cerebral hemodynamic parameters are limited by the presence of cerebros...

The brain has been considered an index organ for global tissue perfusion because of the physiological processes aimed at flow preservation to vital organs of the body[1].When cerebral perfusion is compromised, other organs are likely inadequately perfused as well. It would therefore be prudent to monitor cerebral perfusion based on the proposition that interventions aimed at its preservation wi...

In spite of recent advances in thoracic aortic surgery, postoperative neurological injury still remains the main cause of mortality and morbidity after aortic arch operation. The use of cardiopulmonary bypass (CPB) and hypothermic circulatory arrest, temporary interruption of brain circulation, transient cerebral hypoperfusion, and manipulations on the frequently atheromatic aorta all produce n...

In fetuses with complex congenital heart disease (CHD), impaired brain growth and development starts in utero. A interplay between heart, brain, body placenta takes place the second third trimesters of pregnancy. Altered fetal cardiovascular hemodynamics due to differnt types CHD lead altered cerebral, placental perfusion, all factors contributing maturational delay development. Impaired cerebr...

The ability to assess brain tumor perfusion and abnormalities in the vascular structure in vivo could provide significant benefits in terms of lesion diagnosis and assessment of treatment response. Arterial spin labeling (ASL) has emerged as an increasingly viable methodology for non-invasive assessment of perfusion. Although kinetic models have been developed to describe perfusion in healthy t...

PURPOSE Ceria engineered nanomaterials (ENMs) have current commercial applications and both neuroprotective and toxic effects. Our hypothesis is that ceria ENMs can associate with brain capillary cells and/or cross the blood-brain barrier. METHODS An aqueous dispersion of ∼5 nm ceria ENM was synthesized and characterized in house. Its uptake space in the Sprague Dawley rat brain was determine...

In patients with discirculatory encephalopathy the influence of verbal fluency test on the characteristics of cerebral perfusion, DC-potentials of the brain, as well as on blood pressure and heart rate was investigated. Two patterns of responses to the verbal fluency test were observed. The first one is the process of generalized activation, manifested by the reduction of the TTP (time to peak)...