background: stem cells from human exfoliated deciduous teeth (shed) have the capability to differentiate into neural cells. neurotrophins including nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), and neurotrophin-4 (nt-4) have neurogenesis, neurotrophic, or neuroprotective effects and are expressed in developing teeth. the aim of this study was to mea...

BACKGROUND Dysregulation in the prefrontal cortex-nucleus accumbens pathway has been implicated in cocaine addiction. We have previously demonstrated that one intra-dorsomedial prefrontal cortex brain-derived neurotrophic factor (BDNF) infusion immediately following the last cocaine self-administration session caused a long-lasting inhibition of cocaine-seeking and normalized the cocaine-induce...

PBS: Phosphate Buffered Saline; CSPG: Chondroitin Sulfate Proteoglycans; ChABC: Chondroitinase ABC; SUR1–TRPM4 : Sulfonylurea Receptor 1–Transient Receptor Potential Melastatin 4, PTEN: Phosphate and Tensin Homolog; mTOR: Mammalian Target of Rapamycin; SOCS3: Suppressor of Cytokine Signaling 3; BDNF: Brain -Derived Neurotrophic Factor; LINGO-1: Leucine Rich Repeat and Ig Domain Containing 1; Tr...

Gilland, Kaitlyn Elizabeth. M.S., Purdue University, May 2016. Short-Term Effects of a Western Diet on the Number of Brain-Derived Neurotrophic Factor Immunoreactive Neurons in the Hypothalamic Arcuate, Ventromedial and Paraventricular Nuclei. Major Professor: Edward Fox. Brain-derived neurotrophic factor (BDNF) is an important anorexogenic factor and has been shown to be involved in obesity. I...