High-grade pancreatic intraepithelial neoplasia (PanIN-3) is recognized as a precursor lesion of invasive ductal carcinoma (IDC). However, histological evidence that PanIN-3 invades beyond the basement membrane of pancreatic ductal epithelium, that is, the moment PanIN-3 becomes IDC, has not been captured yet. This may be because PanINs which are microscopic papillary or flat lesion rarely deve...

The bounded diameter minimum spanning tree problem is an NP-hard combinatorial optimization problem arising, for example, in network design when quality of service is of concern. We solve a strong integer linear programming formulation based on so-called jump inequalities by a Branch&Cut algorithm. As the separation subproblem of identifying currently violated jump inequalities is difficult, we...

The metacerebral cell (MCC) of Aplysia californica was isolated with its bifurcate axon from the cerebral ganglion and maintained in vitro under three conditions: (a) with no targets, (b) with identified buccal ganglion neurons B1 or B2 placed near the stump of the large diameter cerebral-buccal connective (CBC) branch, and (c) with B1 or B2 placed near the stump of the small diameter posterior...

Problem statement: Atherogenesis is affected by hemodynamic parameters, such as wall shear stress and wall shear stress spatial gradient. These parameters are largely dependent on the geometry of arterial tree. Arterial bifurcations contain significant flow disturbances. Approach: The effects of branch angle and vessel diameter ratio at the bifurcations on the wall shear stress distribution in ...

AIMS We investigated whether routine T-stenting reduces restenosis of the side branch as compared with provisional T-stenting in patients with de novo coronary bifurcation lesions. METHODS AND RESULTS Our randomized study assigned 101 patients with a coronary bifurcation lesion to routine T-stenting with sirolimus-eluting stents (SES) in both branches and 101 patients to provisional T-stentin...

A76-year-old woman who had a coronary artery bypass using a sequential saphenous vein graft to the diagonal branch and the left anterior descending artery (LAD) remained free of chest pain for 22 years. She was recently diagnosed with critical aortic valve stenosis. Cardiac catheterization showed the sequential saphenous vein graft was patent. The size of the graft was remodeled according to th...

A method for quantitative assessment of tree structures is reported allowing evaluation of airway or vascular tree morphology and its associated function. Our skeletonization and branch-point identification method provides a basis for tree quantification or tree matching, tree-branch diameter measurement in any orientation, and labeling individual branch segments. All main components of our met...

Introduction The ideal animal model for nerve regeneration studies is the object of controversy, because all models described by the literature have advantages and disadvantages. Objective To describe the histologic and functional patterns of the mandibular branch of the facial nerve of Wistar rats to create a new experimental model of facial nerve regeneration. Methods Forty-two male rats were...

AIMS In coronary bifurcations assessment, evaluation of side-branch (SB) ostia by an optical coherence tomography (OCT) pullback performed in the main branch (MB) could speed up lesion evaluation and minimize contrast volume. Dedicated software that reconstructs the cross-sections perpendicular to the SB centreline could improve this assessment. We aimed to validate a new method for assessing t...

AIM To assess the procedural success and major cardiac event rate after stenting of coronary bifurcation lesions. METHODS The prospective study included 36 patients with coronary artery bifurcation lesion treated with stenting between January 1999 and December 2001 at the Institute for Heart Disease, Skopje University Center. There were 23 men and 13 women, with a mean age of 62.5+/-12.3 year...