BACKGROUND Few studies have shown that the association between mammographic breast density and breast cancer persists for up to 10 years after the mammogram. We investigated associations of percent density, absolute dense, and nondense areas with breast cancer risk according to the time since the mammogram. METHODS This study included 1,028 incident breast cancer cases diagnosed within the Nu...

BACKGROUND Mammographic density is a strong risk factor for breast cancer, usually measured by an area-based threshold method that dichotomizes the breast area on a mammogram into dense and nondense regions. Volumetric methods of breast density measurement, such as the fully automated standard mammogram form (SMF) method that estimates the volume of dense and total breast tissue, may provide a ...

BACKGROUND Risk of invasive cancer following treatment for ductal carcinoma in situ (DCIS) is associated with both treatment- and tumor-related factors. However, it is unknown whether stromal factors such as breast density may also influence subsequent invasive breast events. We investigated whether breast density is an independent predictor of subsequent breast events among women treated for D...

We propose to model breast tissue in mammograms covering both density and tissue patterns. The breast tissue density modelling is based on the global density distribution of the breast region. We segment the whole breast region into a number of uniform density sub-regions and construct an overall density model of the breast using the relative proportions of these sub-regions. The breast tissue ...

Mammographic density is a major risk factor for breast cancer. Breast density is not routinely quantified for research studies because present methods are time intensive and manual, and require expert training. We investigated whether individuals with and without backgrounds in radiology or medicine can achieve sufficient accuracy when compared with an expert (gold standard) reader of mammograp...

Mammographic density is one of the strongest predictors of breast cancer risk. Recently, it has been suggested that reactive oxygen species may influence breast cancer risk through its influence on mammographic density. In the current study, we addressed this hypothesis and also assessed if the association between carotenoids and breast cancer risk varies by mammographic density. We conducted a...

BACKGROUND Women with elevated mammographic density have an increased risk of developing breast cancer. However, among women diagnosed with breast cancer, it is unclear whether higher density portends reduced survival, independent of other factors. METHODS We evaluated relationships between mammographic density and risk of death from breast cancer and all causes within the US Breast Cancer Su...

The amount of tissue available in the breast, commonly characterized by the breast density, is highly correlated with breast cancer. In fact, dense breasts have higher risk of developing breast cancer. On the other hand, breast density influences the mammographic interpretation since it decreases the sensitivity of breast cancer detection. This sensitivity decrease is due to the fact that both ...

Breast density has been defined as an important risk factor for the development of breast cancer [1] but the mechanisms of the impact on breast cancer development remain unsolved. One of the main discussions is the definition of breast density. Traditionally breast density is derived by dividing the area of the fibroglandular tissue in the image by the area of the total breast. From a physics p...