Molecular targeting with exogenous near-infrared excitable fluorescent agents using time-dependent imaging techniques may enable diagnostic imaging of breast cancer and prognostic imaging of sentinel lymph nodes within the breast. However, prior to the administration of unproven contrast agents, phantom studies on clinically relevant volumes are essential to assess the benefits of fluorescence-...

OBJECTIVES To investigate: (1) the variability of mammographic compression parameters amongst Asian women; and (2) the effects of reducing compression force on image quality and mean glandular dose (MGD) in Asian women based on phantom study. METHODS We retrospectively collected 15818 raw digital mammograms from 3772 Asian women aged 35-80 years who underwent screening or diagnostic mammograp...

In breast elastography, breast tissues usually undergo large compressions resulting in significant geometric and structural changes, and consequently nonlinear mechanical behavior. In this study, an elastography technique is presented where parameters characterizing tissue nonlinear behavior is reconstructed. Such parameters can be used for tumor tissue classification. To model the nonlinear be...

A new breast imaging technique has been developed and tested for the stereoscopic representation of the breast. The method uses markers at specific locations on the breast surface and standard mammographic projections and was tested with an anthropomorphic phantom containing five mass-like objects at locations determined by a CT scan. The phantom was imaged with a GE Senographe 2000D digital sy...

This paper presents a novel stochastic microwave method for the detection, location and reconstruction of electric properties of breast cancer in a simplified breast phantom. The method is based on the inversion of time domain data. The problem is recast as an optimization one by defining a suitable cost function which is then minimized using an efficient evolutionary algorithm. Selected numeri...

A 32-channel time-resolved imaging device for medical optical tomography has been employed to evaluate a scheme for imaging the human female breast. The fully automated instrument and the reconstruction procedure have been tested on a conical phantom with tissue-equivalent optical properties. The imaging protocol has been designed to obviate compression of the breast and the need for coupling f...

Amputation of a body part, whether as a result of trauma or surgical intervention, is almost always associated with awareness of, and sensations referred to, the missing body part. These sensations were first noted by Ambroise Pare, a French military surgeon in the middle of the 16th century. Mitchel first used the term `phantom' in 1871 from his observations and medical studies of the American...

PURPOSE Photon counting spectral breast CT is feasible in part due to using an adaptive filter. An adaptive filter provides flat x-ray intensity profile and constant x-ray energy spectrum across detector surface, decreases required detector count rate, and eliminates beam hardening artifacts. However, the altered x-ray exposure profiles at the breast and detector surface may influence the distr...

This study was carried out to investigate the suitability of using the optically stimulated luminescence dosimeter (OSLD) in measuring surface dose during radiotherapy. The water equivalent depth (WED) of the OSLD was first determined by comparing the surface dose measured using the OSLD with the percentage depth dose at the buildup region measured using a Markus ionization chamber. Surface dos...