Medium-sized and medium-bridged rings are attractive structural motifs in natural products and therapeutic agents. Due to the unfavourable entropic and/or enthalpic factors with these ring systems, their efficient construction remains a formidable challenge. To address this problem, we herein disclose a radical-based approach for diversity-oriented synthesis of various benzannulated carbon- and...

Since the Human Genome Project was completed, much attention has been given to genome technologies to regulate target gene expression or function. The most simple and promising approach to down-regulate target gene expression in a living cell is antisense strategy, which prevents translation by hybridization of an oligonucleotide with its complementary RNA strand. For practical use in antisense...

We have investigated the reaction products of several iron(III) compounds with hydrogen peroxide, and have found that hydrogen peroxide promotes the formation of an oxo-bridged iron(III) species in the presence of methanol (electron donor), and carboxyl groups of the ligand systems play a role to give the tetranuclear iron(III) compound containing a bent Fe-O-Fe unit (O: oxo oxygen atom). Based...

Flavonoids are a large family of compounds associated with a broad range of biologically useful properties. In recent years, synthetic compounds that contain two flavonoid units linked together have attracted attention in drug discovery and development projects. Numerous flavonoid dimer systems, incorporating a range of monomers attached via different linkers, have been reported to exhibit inte...

Epindolidione (H2L), a heteroatom-modified analogue of tetracene and structural isomer indigo, forms dinuclear complexes with [RuX2]2+, X=bpy (2,2′-bipyridine, [1]2+) or pap (2-phenylazopyridine, [2]2+), in its doubly deprotonated bridging form μ-L2−. The dications compounds meso-[1](ClO4)2 meso-[2](ClO4)2, [X2Ru(μ-L)RuX2](ClO4)2, contain five-membered chelate rings N-C−C-O-RuII π bridged metal...

The role of thiophene bridges in determining the photophysical properties of bridged core-modified hexaphyrins is investigated. Depending on the substituted chalcogen atoms and conjugational perturbation across the thiophene bridges, the bridged core-modified hexaphyrins reveal unique photophysical properties.

The E-4,4'-bis[di(p-anisyl)amino]stilbene cation is a class-III mixed-valence species with electronic coupling comparable to that in its biphenyl-bridged analogue, whereas its tolane-bridged analogue belongs to class II.

A series of 8 new complexes of titanium and zirconium with diamido ligands bearing an ethylene and propylene bridge between the two amido groups were synthesized and tested for ethylene polymerization. Titanium complexes bearing an ethylene bridge between the two amido groups showed higher activities than the derivatives with a propylene bridge. In the case of the zirconium complexes, the p...