β3-adrenergic receptor (AR) and the downstream signaling, nitric oxide synthase (NOS) isoforms, have been emerged as novel modulators of heart function and even potential therapeutic targets for cardiovascular diseases. However, it is not known whether β3-AR plays cardioprotective effects against myocardial infarction (MI) injury. Therefore, the present study was designed to determine the effec...

BACKGROUND We investigated the role of cyclic nucleotide phosphodiesterases (PDEs) in the spatiotemporal control of intracellular cAMP concentrations in rat aortic smooth muscle cells (RASMCs). METHODOLOGY/PRINCIPAL FINDINGS The rank order of PDE families contributing to global cAMP-PDE activity was PDE4> PDE3  =  PDE1. PDE7 mRNA expression but not activity was confirmed. The Fluorescence Res...

The paper extracted pertinent aspects of 21 years (1981-2001) of scientific cooperation among Zimbabwe's Blair Research Laboratory (BRL), the Biomedical Research and Training Institute (BRTI), and the Danish Bilharziasis Laboratory (DBL). DBL supported the building of research capacity at BRL through PhD-level training and short courses on research training organized by BRTI. The BRL-BRTI-DBL c...

This paper deals with a state feedback H∞ control problem for linear time-invariant discrete-time descriptor systems with norm-bounded parametric uncertainties. To this end, bounded real lemma (BRL) is extended on the class of uncertain descriptor systems. The control design procedure based on the conditions of BRL for uncertain descriptor systems is proposed. Numerical example is included to i...

Learning the enormous number of parameters is a challenging problem in model-based Bayesian reinforcement learning. In order to solve the problem, we propose a model-based factored Bayesian reinforcement learning (F-BRL) approach. F-BRL exploits a factored representation to describe states to reduce the number of parameters. Representing the conditional independence relationships between state ...

Bayesian Reinforcement Learning (BRL) provides an optimal solution to on-line learning while acting, but it is computationally intractable for all but the simplest problems: at each decision time, an agent should weigh all possible courses of action by beliefs about future outcomes constructed over long time horizons. To improve tractability, previous research has focused on sparsely sampling p...

Multiplication-stimulating activity (MSA) produced by Buffalo rat liver cells (BRL-3A) in culture is related to the somatomedin family of growth regulatory polypeptides. MSA will stimulate glucose transport and DNA synthesis in normal chicken embryo fibroblasts (CEF) at concentrations of 10-200 ng/ml. MSA found in BRL-3A-conditioned medium, like the somatomedins in serum, does not exist as the ...

The ob gene product is known to control food intake and energy expenditure. To determine whether thermogenic agents directly control ob gene expression, the effects of beta-adrenoceptor agonists on the level of the ob gene messenger RNA (mRNA) and on leptin secretion have been studied in mouse brown adipocytes differentiated in culture. These cells highly expressed the beta 3-adrenoceptor, the ...

The objective of this study is to investigate the differences of acupuncture effect between the Zusanli (St.36) and Sanyinjiao (SP.6) points on the gastrointestinal-tract (GIT) segment performed by the bioavailability of (99m)Tc-sodium-pertechnetate (Na(99m)TcO(4)) in rats. Male Wistar rats (n = 21) were allocated into three groups of seven each. Group 1 was treated by acupuncture bilaterally a...