Background The concept of Atopic march was developed to study the progress of Atopic Dermatitis to Allergic Rhinitis to Asthma. Epidemiologic studies have constantly demonstrated strong associations between Rhinitis and Asthma. Bronchial hyper-reactivity is an important component in the definition of Asthma. Many patients with Allergic Rhinitis have lower Airway hyperreactivity or bronchial hyp...

CHEST I 100 I 6 I DECEMBER, 1991 1741 1 Rolla C, Bucca C, Costa F, Calleris V. Castenetto E, Brussino L. Methacholine bronchial responsiveness in mitral valve disease before and after valve replacement [abstract]. Am RF’/ Respir Dis 1990; 141:A730 2 Nishimura Y, Maeda H, Yokoyama M, Fukuzaki H. Bronchial hyperreactivity in patients with mitral valve disease. Chest 1990; 98:1085-90 3 Nishimura Y...

BACKGROUND Antibody deficiency comprises a heterogeneous group of disorders characterised by the body's inability to mount an effective antibody response to pathogens. Although it has been reported that asthma and allergic disease are frequent in antibody deficiencies, there are no data that evaluate and compare bronchial hyperreactivity (BHR) in all groups of antibody deficiencies. In this stu...

BACKGROUND Allergic rhinitis and asthma may be associated, bronchial hyperreactivity (BHR) is quite common in AR patients. It has been reported that allergen bronchial challenge induces nasal inflammation. Methacholine (MCH) is a stimulus able to elicit BHR. There is no study that investigated the effect of MCH bronchial challenge on the nose. OBJECTIVE The aim of this study was to evaluate w...

BACKGROUND Several epidemiologic studies showed the significant association of insulin resistance with asthma. OBJECTIVE The aim of this study was to evaluate the association of insulin resistance with airway hyperresponsiveness (AHR) in adult population. METHODS 1,058 subjects who visited to the Seoul National University Hospital Gangnam Center from October 2007 to January 2009 for a routi...

I has been recognized for many years that patients with asthma have increased levels ofbronchial responsiveness to pharmacologic, physical, and chemical stimuli. The level of responsiveness correlates reasonably with the severity of asthma.' The association between bronchial hyperrespon-siveness and bronchial asthma is not absolute. Occupational asthma may occur in the absence of hyperresponsiv...

This review is written to summarize and critically analyze pathogenesis of bronchial hyperreactivity (BHR) as an underlying outcome for suitable treatment options. It describes and discusses the role of genetic predisposition, inflammatory mediators and other endogenous factors (growth factors, nuclear transcription factors), neural regulation and proinflammatory neurotransmitter in the pathoge...