BACKGROUND In epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), the tyrosine-kinase inhibitor gefitinib is in broad use. We retrospectively analysed data for 82 patients with advanced NSCLC treated with gefitinib and correlated benefits with clinical baseline and therapy-related parameters. PATIENTS Of all patients 48/82 were male; the median age at start of ...

OBJECTIVE To test the hypothesis that total liquid ventilation enables a more effective and better tolerated lavage than a bronchoalveolar lavage performed with diluted surfactant in a newborn ovine model of severe acute meconium aspiration syndrome. DESIGN Prospective, randomized, interventional study. SETTING Animal research laboratory at the Faculté de médecine et des sciences de la sant...

Bronchoalveolar lavage fluid from 43 patients with biopsy proved sarcoidosis and 10 control subjects were assayed for fibronectin and collagenase activity. Fibronectin was significantly increased in the group with sarcoidosis and was found to be positively correlated with angiotensin converting enzyme activity, protein concentration, percentage of T cells and helper:suppressor ratios in the lav...

INTRODUCTION Lipoid pneumonia is a rare form of pneumonia caused by inhalation or aspiration of fat containing substances like, petroleum jelly, mineral oils, few laxatives etc. It usually presents as insidious onset chronic respiratory illness simulating interstitial lung diseases. Rarely, it may present as an acute respiratory illness, specially, when exposure to fatty substance is acute and/...

Lipoid pneumonia is a rare form of pneumonia caused by inhalation or aspiration of fat-containing substances like petroleum jelly, mineral oils, certain laxatives, etc. It usually presents as an insidious onset, chronic respiratory illness simulating interstitial lung diseases. Rarely, it may present as an acute respiratory illness, especially when the exposure to fatty substance(s) is massive....

The sensitivity of all fiberoptic bronchoscopic techniques in case of a peripheral lung cancer is 69%. In the study, it was aimed to assess the contribution of broncoalveolar lavage (BAL) performed before and after standard biopsy procedures in the diagnosis of peripheral lung cancer. The patients with peripheral lung lesion in radiology, and normal bronchoscopic findings were included in the s...

mucoepidermoid carcinoma of the pancreas is rare. here, a 63-year-old woman with left upper abdominal pain and abdominal distension is presented. her mucoepidermoid carcinoma was located at the left upper abdomen, arising from the pancreatic body and tail without invasion of pancreatic capsule. on pathologic examination, the tumor consisted of three types of cells, the majority being poorly dif...

gastroesophageal reflux disease (gerd)  is defined with clinical symptoms  of  heart burning and regurgitation. it may be associated with external esophageal symptoms such as chronic cough, asthma, laryngitis, chronic lung disease, sinusitis and pulmonary fibrosis. in the present study, rats with chronic aspiration of gastroduodenal contentswere studied for  cellular phenotypes  and  cytokine c...