نتایج جستجو برای: brown adipose tissue

تعداد نتایج: 966615  

Journal: :Biochimica Et Biophysica Acta - Molecular And Cell Biology Of Lipids 2021

Disruption of circadian (~24 h) rhythms is associated with an increased risk cardiometabolic diseases. Therefore, unravelling how are regulated in different metabolic tissues has become a prominent research focus. Of particular interest brown adipose tissue (BAT), which combusts triglyceride-derived fatty acids and glucose into heat displays circannual diurnal rhythm its thermogenic activity. I...

Journal: :Proceedings of the Nutrition Society 1989

Journal: :Journal of Biological Chemistry 1968

Journal: :American journal of physiology. Endocrinology and metabolism 2015
Jasper M A de Jong Ola Larsson Barbara Cannon Jan Nedergaard

The nature of brown adipose tissue in humans is presently debated: whether it is classical brown or of brite/beige nature. The dissimilar developmental origins and proposed distinct functions of the brown and brite/beige tissues make it essential to ascertain the identity of human depots with the perspective of recruiting and activating them for the treatment of obesity and type 2 diabetes. For...

Journal: :Journal of the Royal Society of Medicine 1983

Journal: :Journal of clinical pathology 1989
M E Lean G Jennings

Brown adipose tissue was investigated in two cases of cot death in which core temperatures were above 40 degrees C on arrival at the mortuary. Evidence was obtained from mitochondrial (8-3H) guanosine diphosphate (GDP) binding and oxygen uptake of active thermogenesis with uncoupled mitochondrial respiration which was recoupled by GDP. Thermogenic capacity of brown adipose tissue, estimated by ...

Journal: :The Journal of biological chemistry 2004
Kenneth A Longo Wendy S Wright Sona Kang Isabelle Gerin Shian-Huey Chiang Peter C Lucas Mark R Opp Ormond A MacDougald

Wnt is a family of secreted signaling proteins that regulate diverse developmental processes. Activation of canonical Wnt signaling by Wnt10b inhibits differentiation of preadipocytes in vitro. To determine whether Wnt signaling blocks adipogenesis in vivo, we created transgenic mice in which Wnt10b is expressed from the FABP4 promoter. Expression of Wnt10b in adipose impairs development of thi...

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