objective: crocin is an active ingredient of saffron (crocus sativus l.) and its antioxidant properties have been previously investigated. this carotenoid scavenges free radicals and stimulates glutathione (gsh) synthesis; consequently, it may protect cells against oxidative stress. the aim of this research is to protect oocytes from oxidative stress by the addition of a natural source antioxid...

Background Women with early ovarian hormone deprivation due to bilateral salpingo-oophorectomy (BSO; and fallopian tube removal) are at risk for later life Alzheimer’s disease (AD), but estradiol therapy (ET) may be protective (Rocca et al., 2007). Working memory (WM), temporarily maintaining manipulating information in mind, depends on structural integrity of fronto-parietal brain regions (Bur...

The convergence and divergence are two common phenomena in swarm intelligence. To obtain good search results, the algorithm should have a balance on convergence and divergence. The premature convergence happens partially due to the solutions getting clustered together, and not diverging again. The brain storm optimization (BSO), which is a young and promising algorithm in swarm intelligence, is...

Behavioural Supports Ontario (BSO) was launched to enhance the healthcare services for Ontario's seniors, their caregivers and families living and coping with responsive behaviours associated with dementia and other neurological conditions. The implementation of the program varied across and within the local health integration networks (LHINs). By 2015, there were three BSO models operating wit...

Brain storm optimization algorithm (BSO) is a popular swarm intelligence algorithm. A significant part of BSO to divide the population into different clusters with clustering strategy, and blind disturbance operator used generate offspring. However, this mechanism easy lead premature convergence due lacking effective direction information. In paper, an enhanced based on modified Nelder–Mead eli...

Arsenic trioxide (ATO) is an effective therapeutic agent for acute promyelocytic leukaemia (APL) (Evens et al, 2004). In APL, ATO induces differentiation at low concentrations, while inducing apoptosis at higher concentrations (Miller et al, 2002). In addition, ATO-induced apoptosis in APL is mediated through the mitochondrial apoptotic pathway, resulting in part from the production of reactive...

Depletion of glutathione (GSH) from CYP2E1-expressing cells by treatment with l-buthionine sulfoximine (BSO) causes decreased cell viability. The possible role of mitogen-activated protein kinases (MAPK) in this toxicity was evaluated. SB203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole], an inhibitor of p38 MAPK decreased the BSO-dependent toxicity in HepG2 E47 ce...

Objective. To report on the use of laparoendoscopic single-site surgery (LESS) for the management of total hysterectomy (TH) with bilateral salpingoovariectomy (BSO) in a subject affected by gender identity disorder. Design. Case report. Setting. University Hospital. Patient(s). A 27-year-old affected by Gender Identity Disorder underwent a hysterectomy and BSO as part of surgical sex reassignm...

Bcl-2 protein plays a critical role in inhibiting anticancer drug-induced apoptosis. We found that Bcl-2 overexpression is associated with a nearly 3-fold increase in cellular glutathione levels and with increased resistance to cell death after treatment with etoposide or SN-38, a derivative of camptothecin, in leukemia 697 cells with wild-type p53. Treatment of Bcl-2-overexpressing 697 cells (...

The effect and therapeutic consequences of buthionim--(.S'A)-sulfoximine (BSO)-inediated depletion of glutathione in the human medulloblastoma-derived cell line, TE-671, growing as s.c. xenografts in athymic nude mice were examined. The glutathione content of the s.c. xenografts was 1.11 ±0.15(imol/g(7.79± 1.61 nmol/mgof protein). Administration i.p. to tumor-bearing mice of n.i.-BSO (two dos...