Bupropion has been found to be a useful pharmaceutical agent in furthering smoking abstinence. Preclinical research investigating the effects of bupropion on nicotine self-administration has indicated bupropion has selective effects on nicotine self-administration. However since response rates maintained by nicotine were significantly lower than rates of response maintained by the non-drug rein...

BACKGROUND The chronic pain can disturb physical, psychological, and social performances. Analgesic agents are widely used but some antidepressants (ADs) showed analgesia also. Bupropion is using for smoke cessation but it can change morphine withdrawal signs such as pain. This study tested the acute systemic effect of bupropion on formalin induced pain behavior in rats. METHODS Wistar male h...

The potential of inhibitory metabolites of perpetrator drugs to contribute to drug-drug interactions (DDIs) is uncommon and underestimated. However, the occurrence of unexpected DDI suggests the potential contribution of metabolites to the observed DDI. The aim of this study was to develop a physiologically-based pharmacokinetic (PBPK) model for bupropion and its three primary metabolites-hydro...

Bupropion reduces the subjective effects and cue-induced craving for methamphetamine in humans. Given these effects of bupropion on methamphetamine in humans and its widespread clinical use, a preclinical model of drug-taking was used to determine if pretreatment with bupropion would alter the acquisition of methamphetamine self-administration. During acquisition, rats were given saline or bupr...

AIMS Prescribing nicotine replacement therapy (NRT) or bupropion for smoking cessation is of considerable importance to public health but little is known about prescribing practices. This paper examines general practitioners' (GPs') prescribing patterns in Britain where these drugs are reimbursed. The results have implications for other health-care systems considering introducing reimbursement....

OBJECTIVE To evaluate the effectiveness and safety of bupropion sustained-release (SR) for the treatment of neuropathic pain. METHOD This single-center, outpatient, randomized, double-blind, placebo-controlled, crossover study consisted of two phases. Forty-one nondepressed patients with neuropathic pain spent 6 weeks in each phase in random order and received identical tablets of 150 mg bupr...

Background and Objectives: Chlorogenic acid, a natural polyphenolic compound has been reported to possess neuroprotective and antioxidant activities, but the effect of chlorogenic acid on orofacial dyskinesia has not been explored till date, so the aim of the present study was to investigate the effect of chlorogenic acid on reserpine-induced orofacial dyskinesia in Wistar male albino rats. Met...

The mechanism of resistance to the catecholamine depleting effects of reserpine in morphine tolerant rats was examined. In vitro, morphine did not alter reserpine 3 inhibition of H-norepinephrine uptake by synaptic vesicles. Similarly, uptake by vesicles isolated from morphine tolerant animals was as susceptible to reserpine inhibition as that of corresponding preparations from saline treated c...

With pronethalol, quinidine, and reserpine it was necessary to increase the dose of acetylstrophanthidin which produced arrhythmia in combination with vagal stimulation. However, in reserpine-treated animals, quinidine and pronethalol were ineffective. The capability of large doses of acetylstrophanthidin to produce ventricular arrhythmia was not diminished by quinidine, pronethalol, or reserpi...

With pronethalol, quinidine, and reserpine it was necessary to increase the dose of acetylstrophanthidin which produced arrhythmia in combination with vagal stimulation. However, in reserpine-treated animals, quinidine and pronethalol were ineffective. The capability of large doses of acetylstrophanthidin to produce ventricular arrhythmia was not diminished by quinidine, pronethalol, or reserpi...