background thermal injury is associated with several biochemical and histopathological alteration in tissue. analysis of these objective parameters in research and clinical field are common to determine healing rate of burn wound. negative pressure wound therapy has been achieved wide success in treating chronic wounds. this study determines superficial burn wound healing with intermittent nega...

background: minoxidil has been reported to inhibit in vitro fibroblast proliferation and lysyl hydroxylase activity, a key enzyme in collagen biosynthesis. these in-vitro effects proposed minoxidil to be a potential antifibrotic agent. the present study aimed to investigate the effects of minoxidil gel on wound healing procedure in a second-degree burn model in rats.  materials and methods: wis...

conclusions stem cell therapies in wound care may lessen the morbidities associated with wound healing. an ideal method for the effective administration of stem cells for burn patients has not yet been elucidated. further comparison of the local and systemic effects in burn patients, associated with each route of stem cell delivery, needs to be performed. results application of cells to the bur...

INTRODUCTION Burn injury is a medical problem as well as a social burden on the national health services in developing countries. Trace elements have important roles in wound healing and act as antioxidants. In this study, zinc (Zn) and copper (Cu) levels in plasma of burned patients and their relationship with the burn surface area and time-related pattern are determined in the admitted patien...

PURPOSE Severe burn injury leads to marked catabolism and decreased lean mass, which can impair healing. Anabolic agents can attenuate net catabolism. Our purpose was to determine whether the testosterone analog, oxandrolone, given during the acute post burn period decreased the degree of nitrogen loss and loss of body weight while also increasing the healing rate of a skin donor site. MATERI...

Objective-  To evaluate the role of autogenous bone marrow (BM), in the healing of experimentally induced burn wound in rats. Design- Experimental in-vivo study.   Animals- 20 adult male white New Zealand rabbits.   Procedures- Two burn wounds were created under general anesthesia using a 100 W electric soldering iron, heated to the point of redness (about 800° C) on each side of the back, 4...

BACKGROUND Severe burns are a common and highly lethal trauma. The key step for severe burn therapy is to promote the wound healing as early as possible, and reports indicate that mesenchymal stem cell (MSC) therapy contributes to facilitate wound healing. In this study, we investigated effect of human umbilical cord MSCs (hUC-MSCs) could on wound healing in a rat model of severe burn and its p...

Burn wound exudate is an important source of information on the wound-healing process and systemic improvement of burn patients. Identification of biomarkers for the prediagnosis of local or systemic complications in patients will have a great impact on adapting personalized procedures in burn treatment. No efficient exudate collection method exists that offers a direct and continuous collectio...

The events occurring early in the burn wound trigger a sequence of local and systemic responses that influence cell and tissue survival and, consequently, wound healing and recovery. Using high-density oligonucleotide arrays we identified gene expression patterns in skin samples taken from a region of injury in the burn rat model. The associated genomic events include the differential expressio...