Dyspigmentation in burn scars can contribute to the development of psychosocial complications after injury and can be detrimental to social reintegration and quality of life for burn survivors. Although treatments for skin lightening to treat hyperpigmentation have been well reviewed in the literature, skin-darkening strategies to treat hypopigmentation have not. The following potential treatme...

OBJECTIVE This study assessed the role of self-reported facial scar severity as a possible influencing factor on self-esteem and depressive symptoms in patients with facial burns. METHOD A prospective multicentre cohort study with a 6 months follow-up was conducted including 132 patients with facial burns. Patients completed the Patient and Observer Scar Assessment Scale, the Rosenberg Self-e...

  Objective (s): Scar formation in injured peripheral nerve bed causes several consequences which impede the process of nerve regeneration. Several animal models are used for scar induction in preclinical studies which target prevention and/or suppression of perineural scar. This study evaluates the translational capacity of four of physical injury models to induce scar formation aro...

The cutaneous sequelae of burns are usually temporary loss of pigment, hypertrophic scar and keloid. Infrequently skin neoplasia such as squamous cell carcinoma, basal cell carcinoma, malignant melanoma and sarcoma develop within the burn scar. Because ILVEN was developed after a burn in our patient, it is suggested that the possible mechanism for the development of ILVEN may have been that the...

An 18-year-old woman was admitted to Motahari Burn Center suffering from 30% burns. Treatment modalities were carried out for the patient and she was discharged after 20 days. Three to four months later she developed hypertrophic scar on her chest and upper limbs. At the same time she developed galactorrhea in both breasts and had a disturbed menstrual cycle four months post-burn. On investigat...

BACKGROUND Problematic scarring remains a challenging aspect to address in the treatment of burns and can significantly affect the quality of life of the burn survivor. At present, there are few treatments available in the clinic to control adverse scarring, but experimental pharmacological anti-scarring strategies are now beginning to emerge. Their comparative success must be based on objectiv...

Porcine thermal burns have been widely employed for examining the beneficial effects of novel burn treatments prior to clinical application and for understanding the mechanisms of burn wound healing 1, 2. The advantages of these porcine burns over other animal burns are well described by others, such as the well described close resemblance to human skin in structure and in wound healing. Import...

Presently, research assessments of burn scar management interventions focus on measures scarring and features. However, qualitative demonstrates that patients experience therapies holistically. Patient-centred assessment should reflect this. An agreement is required regarding what to assess, which tools use at time points. Key issues include (1) whether how burn- or scar-related quality-of-life...

Background: Microneedling is recently used to treat skin scars mostly atrophic scars; however, there are limited data about its effectiveness on hypertrophic burn scars. Carbon dioxide (CO2) laser is an effective method for the treatment of burn scars. Here, we aim to compare the efficacy of microneedling to CO2 laser in the treatment of hypertrophic burn scars in a randomized clinical trial. M...

The majority of full-thickness burn wounds heal with hypertrophic scar formation. Burn eschar most probably influences early burn wound healing, since granulation tissue only forms after escharotomy. In order to investigate the effect of burn eschar on delayed granulation tissue formation, burn wound extract (BWE) was isolated from the interface between non-viable eschar and viable tissue. The ...