The present study is designed to monitor the effects of buspirone and propranolol on responses to stress. Exposure to single (2h) restraint stress decreased food intake, growth rate and time spent in the lit compartment of a light-dark activity box. The deficits were not observed following 5 (2-h/day) restraint stress, suggesting that adaptation occurred. Prior administration of buspirone and p...

BACKGROUND AND THE PURPOSE OF THE STUDY The available literatures show that 5-HT(1A) receptors are widely distributed throughout the basal ganglia, and their activation facilitate dopamine release. Neuroleptic drugs such as haloperidol induce Parkinson-like syndrome through blocking brain D(2) receptors. This study aimed to investigate effect of buspirone, a partial agonist of 5HT(1A) receptor,...

how to cite this article: fayyazi a, salari e, khajeh a, ghajarpour a. a comparison of risperidone and buspirone for treatment of behavior disorders in children with phenylketonuria. iran j child neurol. 2014 autumn; 8(4):33-38. abstract objective many patients with late-diagnosed phenylketonuria (pku) suffer from severe behavior problems. this study compares the effects of buspirone and risper...

The present study characterized the effects of the novel, selective, and potent 5-hydroxytryptamine1A (serotonin) (5-HT1A) receptor agonist, alnespirone [S-20499, (S)-N-4-[5-methoxychroman-3-yl)propylamino)butyl- 8-azaspiro-(4,5)-diacetamide, hydrochloride] on offensive and defensive resident-intruder aggression in wild-type rats and compared its actions with those of the prototypical full 5-HT...

Tobacco withdrawal symptoms hamper smoking cessation. This was a pilot study of buspirone, a new azapirone anxiolytic, for tobacco withdrawal. Thirteen smokers entered an open clinical trial. Smokers were titrated to 30 mg/day of oral buspirone for 2 weeks prior to cessation. Tobacco withdrawal and Spielberger state-anxiety scales were used at baseline, on the quit date, and then at 24 hours, 4...

Mitochondrial toxicity is increasingly implicated in a host of drug-induced organ toxicities, including hepatotoxicity. Nefazodone was withdrawn from the U.S. market in 2004 due to hepatotoxicity. Accordingly, we evaluated nefazodone, another triazolopyridine trazodone, plus the azaspirodecanedione buspirone, for cytotoxicity and effects on mitochondrial function. In accord with its clinical di...