The Suzuki-Miyaura cross-coupling has been widely recognized as one of the most important methods for the construction of C-C bonds. However, in contrast to traditional aryl halide or pseudohalide electrophiles, coupling reactions with unactivated C-N and C-O electrophiles have proven significantly more challenging. Here we report the first general palladium-catalyzed Suzuki-Miyaura cross-coupl...

The Suzuki–Miyaura cross-coupling has been widely recognized as one of the most important methods for the construction of C–C bonds. However, in contrast to traditional aryl halide or pseudohalide electrophiles, coupling reactions with unactivated C–N and C–O electrophiles have proven significantly more challenging. Here we report the first general palladium-catalyzed Suzuki–Miyaura cross-coupl...

Metal-catalyzed C–N cross-coupling generally forms C−N bonds by reductive elimination from metal complexes bearing covalent C- and N-ligands. We have identified a Cu-mediated that uses dative N-ligand in the bond-forming event, which, contrast to conventional methods, generates reactive cationic products. Mechanistic studies suggest process operates via transmetalation of an aryl organoboron Cu...

Neutral and cationic N-methyl- N-phenyl-2-aminobiphenyl methanesulfonate palladacycles stabilized with dialkylterphenyl phosphanes have been prepared characterized. structures are favored the less bulky phosphane PMe2ArXyl2, L1, while more sterically demanding ligands PiPr2ArXyl2, L3, PCyp2ArXyl2 (Cyp = cyclopentyl), L4, lead to complexes in which exhibits a bidentate ?1-P, ?1-Carene coordinati...