Cervical laminoplasty is a valuable procedure for myelopathy but it associated with complications such as increased kyphosis. The effect of ligament damage during cervical on biomechanics not well understood. We developed the C2–C7 spine finite element model and simulated C3–C6 double-door laminoplasty. Three models were created (a) intact, (b) laminoplasty-pre (model assuming that ligamentum f...

with a hydrophobic cluster of Tyr-59, Ile-60 and Leu-63 on one surface. It is this hydrophobic cluster that we suggest is being mimicked by the tryptophanyl-tryptophan groups as illustrated in Fig. 1. We also propose that the hydrophobic cluster in C3a represents a secondary binding site on the molecule, and it is a cooperative interaction on the receptor between the hydrophobic and effector si...

Spontaneous regression of cervical disc herniation is a rare, and such reports are few. A 39 year-old woman complained of severe neck pain associated with tingling and numbness of right upper extremity. The MRI of the cervical spine revealed a posterior disc extrusion at the C4-C5 level in the right para-central location. The patient was treated with conservative management without any surgical...

Immunogenic non-replicative recombinant modified vaccinia virus Ankara (rMVA) has been developed to turn "cold" tumors into "hot" tumors. MVAΔE5R-hFlt3L-mOX40L is our first-generation rMVA by deleting a cGAS (cyclic GMP-AMP synthase) inhibitor encoded the E5R gene and inserting human Flt3L (a growth factor for dendritic cells) murine OX40L co-stimulatory molecule T cells). In this study, we use...

The oxidation of guanine by triplet benzophenone in the presence of lysine has been shown to produce mono- and dilysine-substituted spiroiminodihydantion products, 8-Lys-Sp and 5,8-diLys-Sp. The potential energy surfaces for C8, C5, and C4 nucleophilic addition have been mapped out using the B3LYP/aug-cc-pVTZ//B3LYP/6-31+G(d,p) level of density functional theory with the SMD solvation model and...

Serum C1q, C3, C4, and C5 components of complement levels were measured in 35 healthy subjects and 29 patients with acute conjunctivitis due to adenovirus type 2, 7, and 8 infections. Serum C1q and C3 levels were found to be significantly low, and there was no change in serum C4 and C5 levels. A progressive decline in the serum complement level with the severity of disease was observed. The cha...