Mycolic acid-producing bacteria isolated from the respiratory tract of human and non-human mammals were recently assigned as a distinct genus, Segniliparus, because they diverge from rhodococci and mycobacteria in genetic and chemical features. Using high accuracy mass spectrometry, we determined the chemical composition of 65 homologous mycolic acids in two Segniliparus species and separately ...

Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity. A variety of cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000) Gene 242, 285-294). The three proteins show ...

In an attempt to grow 8-hy-droxy-quinoline-acetamino-phen co-crystals from equimolar amounts of conformers in a chloro-form-ethanol solvent mixture at room temperature, the title compound, C9H7NO, was obtained. The mol-ecule is planar, with the hy-droxy H atom forming an intra-molecular O-H⋯N hydrogen bond. In the crystal, mol-ecules form centrosymmetric dimers via two O-H⋯N hydrogen bonds. Thu...

Metabolomics is a promising tool to gain new insights into early metabolic alterations preceding the development of hypertension in humans. We therefore aimed to identify metabolites associated with incident hypertension using measured data of serum metabolites of the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam study. Targeted metabolic profiling was conducted on...

Signal transducer and activator of transcription 5 (Stat5) plays an important role in the transition of prostate cancer (PCa) to its castrate-resistant state. Pharmacologic targeting of Stat5 is a rational approach to delay castrate-resistant progression, in part, because Stat5 cooperates with the androgen receptor (AR) to promote PCa progression. Immunostaining of tissue microarrays was used t...

We derive a class of composite estimators of small-area quantities that exploit spatial (distance-related) similarity. They are based on a distribution-free model for the areas, but the estimators are aimed to have optimal design-based properties. Composition is applied also to estimating some of the global parameters on which the small-area estimators depend. We show that the commonly adopted ...

Activation of the classical complement (C) system involves conversion of C1 to its active state with subsequent cleavae of C4 and C2 so as to form the classical C3 convertase, C42 (a bar indicates the activated form of a protein), which sequentially cleaves C3 and CS to initiate the cytolytic event associated with the complete reaction. An alternative, or properdin-dependent, pathway to complem...

in very recent papers asmild et al. (2003) and halved et al. (2004) based upon potential improvement efficiency index (bogetoft and hougaard,1999) have suggested an alternative nonparametric frontier approach namely multi-directional inefficiency analysis (mea) to estimate the performance efficiency. mea has many advantages over data envelopment analysis (dea) as the standard nonparametric fron...