TOPIC: Pulmonary Manifestations of Systemic Disease TYPE: Medical Student/Resident Case Reports INTRODUCTION: Anti-MDA5 (anti-melanoma differentiation-associated gene-5) associated dermatomyositis (DM) is a rare presentation idiopathic inflammatory myositis, often presenting with treatment refractory rapidly progressing interstitial lung disease (ILD). Diagnosis difficult as patients can presen...

The skin of carp, Cyprinus carpio, was studied at the ultrastructural level after exposure of the fish to low and high concentrations of cadmium in the water (22 and 560 fxg/L, respectively) for different periods. The effects of the low con­ centration of cadmium were similar to those of the high concentration, although they appeared later. The basal lamina and the skin surface became highly un...

The skin of carp, Cyprinus carpio, was studied at the ultrastructural level after exposure of the fish to low and high concentrations of cadmium in the water (22 and 560 fxg/L, respectively) for different periods. The effects of the low con­ centration of cadmium were similar to those of the high concentration, although they appeared later. The basal lamina and the skin surface became highly un...

In this issue of Rheumatology, Kurita et al. [1] assess the effect of tacrolimus in patients with interstitial lung disease (ILD) and idiopathic inflammatory myopathy (IIM). Long-term survival in IIM has improved over the last 20 years but remains relatively poor. Ten-year survival in the UK is 90%, comparable with SLE [2]. ILD, which occurs in 30% of IIM cases, is a major predictor of death, y...