Today's medical world has gained a growing appeal towards CAM/TM which can be seen in the strategies of US in the form of establishing National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health (NIH) and White House Commission on Complementary and Alternative Medicine Policy (WHCCAMP) at the White House, the annual increase of integration of CAM clas...

Today's medical world has gained a growing appeal towards CAM/TM which can be seen in the strategies of US in the form of establishing National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health (NIH) and White House Commission on Complementary and Alternative Medicine Policy (WHCCAMP) at the White House, the annual increase of integration of CAM clas...

The 18.5-kDa myelin basic protein (MBP), the most abundant isoform in human adult myelin, is a multifunctional, intrinsically disordered protein that maintains compact assembly of the sheath. Solution NMR spectroscopy and a hydrophobic moment analysis of MBP's amino-acid sequence have previously revealed three regions with high propensity to form strongly amphipathic α-helices. These regions, l...

Portulacaria afra (L.) Jacq., a perennial facultative Crassulacean acid metabolism (CAM) species, was studied under natural photoperiods and temperatures in San Diego, California. The plants were irrigated every fourth day throughout the study period. Measurements of (14)CO(2) uptake, stomatal resistance, and titratable acidity were made periodically from July 1981 through May 1982. P. afra mai...

Phosphatidylinositol-3,4,5-trisphosphate (PIP3) has been proposed to modulate the odorant sensitivity of olfactory sensory neurons by inhibiting activation of cyclic nucleotide-gated (CNG) channels in the cilia. When applied to the intracellular face of excised patches, PIP3 has been shown to inhibit activation of heteromeric olfactory CNG channels, composed of CNGA2, CNGA4, and CNGB1b subunits...

D2 is a membrane glycoprotein that is believed to function as a cell adhesion molecule (CAM) in neural cells. We have examined its biosynthesis in cultured fetal rat brain neurones. We found D2-CAM to be synthesized initially as two polypeptides: Mr 186,000 (A) and Mr 136,000 (B). With increasing chase times the Mr of both molecules increased to 187,000-201,000 (A) and 137,000-158,000 (B). Thes...

Isometrically suspended uteri from estrogen-primed rats were stimulated with prostaglandin F2 alpha and then exposed to relaxin. Relaxin-dependent decreases in the ratio of phosphorylated to total myosin light chains (MLC) and in MLC kinase activity, measured in the presence of 0.5 mg/ml of uterine myosin and the absence and presence of Ca2+-calmodulin (CaM), were observed. The time-course and ...

T accustomed to rapid resolution of urologic disease by surgical or endoscopic procedures, urologists have only recently begun to apply complementary and alternative methods to patient care. With the concurrent shift toward an office-based process of care, urologists have responded to patient-driven trends toward wellness, self-healing, and nutraceutic and phytotherapies and have recognized the...

The rodent neural cell adhesion molecule (N-CAM) consists of three glycoprotein chains of 180, 140, and 120 kD in their adult forms. Although the proportions of the three components are known to change during development and differ between brain regions, their individual distribution and function are unknown. Here we report studies carried out with a monoclonal antibody that specifically recogn...

We have used electron paramagnetic resonance (EPR) to examine the structural impact of oxidizing specific methionine (M) side chains in calmodulin (CaM). It has been shown that oxidation of either M109 or M124 in CaM diminishes CaM regulation of the muscle calcium release channel, the ryanodine receptor (RyR), and that mutation of M to Q (glutamine) in either case produces functional effects id...