objective(s): although tumor necrosis factor-related apoptosis-inducing ligand (trail) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (nsclc) exhibit trail-resistance. the purpose of this study was to determine whether subtoxic-dose cisplatin and trail could synergistically enhance apoptosis on nsclc cells and investigate its under...

objective(s):the colorectal cancer stem cells (cscs) with the cd133+ phenotype are a rare fraction of cancer cells with the ability of self-renewal, unlimited proliferation and resistance to treatment. quercetin has anticancer effects with the advantage of exhibiting low side effects. therefore, we evaluated the anticancer effects of quercetin and doxorubicin (dox) in ht29 cancer cells and its ...

the theory of contact mechanics deals with stresses and deformations which arise when the surfaces of two solid bodies are brought into contact. in elastic deformation contact occurs over a finite area. a regular method for determining the dimensions of this area is hertz contact model. appearance of atomic force microscope results in introduction of contact mechanics into biology. low elastici...

cancer stem cells (cscs) are unique subpopulations that have the capacity to drive malignant progression with renewal abilities. recently the role of some of cscs in gastric adenocarcinoma has been studied. this study was performed in order to evaluate cd44 and cd133 expressions by immunohistochemistry in 95 primary gastric adenocarcinoma and their relation to clinical and pathological paramete...

background: increasing the complexity in modern radiotherapy techniques have increased the delivery time lowering consequently the treatment efficacy. through simulating the delivery time delay encountered in such techniques, its’ effect on two cancer cell lines and the compensating doses given to prevent such effect was investigated. materials and methods: f10b16 and 4t1 cancer cell lines were...

background propolis is a natural product of bee and caffeic acid phenethyl ester (cape) is a pharmacologically important product of propolis. results cape prevented growth and proliferation of ags human gastric cancer cell line in a concentration-dependent manner with an ic50 of approximately 60 µm by a 24-hour treatment. also cape caused increased induction of apoptosis in ags cells from 1.37 ...

abstract background: gastric cancer is a life threatening disease. recent studies have shown that rosa damascene possesses noticeable biological effects on the human body. this study, investigates the anticancer effect of rosa damascena on gastric cancer cell line mkn45. methods: microscopic studies and mtt assay were used to examine morphological alteration, and cell survival of the cancer cel...

Cancer is now a global concern, and control of the function of cancer cells is recognized as an important challenge. Although many aggressive chemical and radiation methods are in practice to eliminate cancer cells, most imply severe adverse toxic effects on patients. Taking advantage of natural physical differences between cancer and normal cells might benefit the patient with more specific cy...