Toxoplasma gondii contain various immunogenic antigens. The most important Toxoplasma antigens are somatic and excreted/secreted antigens. Rhoptry proteins are known as excreted/secreted antigens. These antigens have been proposed as a vaccine candidate against toxoplasmosis. The main objective of the present work was cloning rhoptry protein1 (ROP1) Gene of Toxoplasma gondii (RH) in a cloning...

Background A specific feature of the autoimmune response in rheumatoid arthritis (RA) is presence anti-citrullinated protein antibodies (ACPAs) patient sera. These can appear several years before disease onset and are involved development RA. Objective We performed proteomic analysis by mass spectroscopy to identify novel citrullinated antigens autoantibodies RA patients. Methods Polypeptides i...

background : production of monoclonal antibodies to leishmania antigens assists the identification and characterization of these organisms. objective: production of monoclonal antibodies against epitopes on the gp63. methods: two murine monoclonal antibodies to gp63 were produced and characterized. the reactions of both antibodies with soluble leishmanial antigens, purified gp63 and truncated r...

While first and foremost considered a respiratory infection, COVID-19 can result in complications affecting multiple organs. Immune responses both protect against the disease as well drive it. Insights into these responses, specifically targets being recognised by immune system, are of vital importance understanding side effects associated pathologies. The body’s adaptive immunity recognises re...

vasectomy is one of the extensively used methods of contraception in family planning programs. antisperm antibodies (asa) develop after vasectomy which can result in auto-immune male infertility. the precise sperm antigens involved in the autoimmune response are still poorly defined, therefore we determined the circulating asa and identified relevant sperm antigens based on localization of bind...

Abstract The Lewis blood group system is unique because antigens are neither alleles of the same gene nor they synthesized by red cells (RBCs); rather, adsorbed onto RBC membrane from plasma as glycolipids. Antibodies against predominantly naturally occurring immunoglobulin (Ig)M type that sometimes react at 37°C and antihuman globulin phase. compound antigens, ALe b BLe , have been described w...

toxoplasma gondii contain various immunogenic antigens. the most important toxoplasma antigens are somatic and excreted/secreted antigens. rhoptry proteins are known as excreted/secreted antigens. these antigens have been proposed as a vaccine candidate against toxoplasmosis. the main objective of the present work was cloning rhoptry protein1 (rop1) gene of toxoplasma gondii (rh) in a cloning v...

background and objectives: angiogenesis is essential for growth and metastasis of solid malignancies. tumor vessel count and expression of vascular endothelial growth factor (vegf), a potent angiogenic factor, have been associated with prognosis. this study was designed to assess vessels density by using cd31 and cd105 (endoglin) and their correlation with expression of vegf and proliferative i...