Advances in treating peripheral nerve lesions have resulted from research in nerve regeneration and the use biomaterials as well as synthetic materials. When direct tensionless repair of peripheral nerve lesions is not possible, nerve conduits may be used to bridge digital sensory nerve gaps of ≤3 cm. Nerve autograft is the benchmark for larger, longer, mixed, or motor nerve defects. Biologic, ...

Objective: The study aimed at obtaining and characterizing levofloxacin-loaded, poly(ε-caprolactone) electrospun nanofiber formulations to be used as antibacterial wound dressings. Methods: Drug-loaded nanofibers were obtained by the electrospinning process and their morphology was determined using scanning electron microscopy. Structural analysis of the prepared nanofibers was carried out usin...

The aim of this study was to prepare nonwoven materials from poly(epsilon-caprolactone) (PCL) and their antibiotic containing forms by electrospinning, so as to prevent postsurgery induced abdominal adhesions in rats. epsilon-Caprolactone was first polymerized by ring-opening polymerization, and then it was processed into matrices composed of nanofibers by electrospinning. A model antibiotic (B...

Cylindrical elastomers were prepared through the UV-initiated crosslinking of terminally acrylated, 8,000 Da star-poly(trimethylene carbonate-co-ε-caprolactone) and star-poly(trimethylene carbonate-co-D,L-lactide). These elastomers were implanted intramuscularly into the hind legs of male Wistar rats to determine the influence of the comonomer on the weight loss, tissue response, and change in ...

Background: Glibenclamide is a lipophilic drug widely used in type 2 diabetes treatment. However, its low bioavailability limits its use. Thus, novel formulations should be applied to improve the drug’s bioavailability. Objectives: This study aimed to develop alternative carriers for oral delivery of glibenclamide. For this purpose, two biocompatible polymers, poly(e-caprolactone) and poly(but...

The Mn2+ and Mo6+ based metal-mercaptoacetate (metal-MA) hybrids were prepared by a simple acid–base titration method. metal-MA analysed FT-IR spectroscopy, UV–visible SEM, particle size analyser (PSA), XRD EDX. investigated to assess their catalytic activity for ring-opening polymerization (ROP) of ε-caprolactone (CL) in the absence an initiator at 160 °C N2 atmosphere varying catalyst concent...

Nanoformulations can play an important role in the improvement of anticancer drug therapies. The bioavailability sorafenib, which is exclusively applied treatment unresectable hepatocellular carcinoma, may be increased by its incorporation a biocompatible nanoparticulate matrix that capable targeting and controlling release. copolymers ε-caprolactone are emerging biodegradable compounds for del...