The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains ha...

Doripenem (formerly S-4661), a new 1-beta-methyl carbapenem, was challenged with a worldwide collection of 394 drug-refractory isolates. For endemic extended-spectrum beta-lactamase- and stably derepressed AmpC-producing enteric bacilli, the doripenem MICs at which 90% of the isolates were inhibited (MIC90s) were 0.03 to 0.5 microg/ml, generally lower than those of comparator carbapenems. A gre...

BACKGROUND Information is limited about the effect of restricted carbapenem use on clearance of multi-drug resistant Acinetobacter baumannii (MDRAB). We sought to determine the time effect of antibiotic exposure on multi-drug resistant Acinetobacter baumannii (MDRAB) acquisition and clearance. METHODS We conducted a retrospective observational study at the intensive care units of a tertiary m...

OBJECTIVE A study was conducted to recover carbapenem-resistant bacteria from the faeces of dairy cattle and identify the underlying genetic mechanisms associated with reduced phenotypic susceptibility to carbapenems. METHODS One hundred and fifty-nine faecal samples from dairy cattle were screened for carbapenem-resistant bacteria. Phenotypic screening was conducted on two media containing e...

References 1 Yigit H, Queenan AM, Anderson GJ et al. Novel carbapenem-hydrolyzing b-lactamase KPC-1 from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 2001; 45: 1151–61. 2 Nordmann P, Naas T, Poirel L. Global spread of carbapenemaseproducing Enterobacteriaceae. Emerg Infect Dis 2011; 17: 1791–8. 3 Naas T, Cuzon G, Truong HV et al. Role of ISKpn7 and deletio...

The concomitant use of carbapenems and valproate is not recommended because carbapenems may decrease serum concentrations of valproate. Increasing the dose of valproate may not compensate for the reduction, which puts the patient at risk for recurrent seizures. Therefore, close monitoring of valproate levels is necessary when initiating a carbapenem antibiotic in patients whose condition has be...

Two hundred and thirty isolates of Pseudomonas aeruginosa were obtained from samples of patients having diabetes (75%), cancer (20%), and both diabetes and cancer (5%) who were admitted to a tertiary care hospital in Western India from January to December 2006. These isolates were tested for susceptibility to antipseudomonal drugs and considered to be resistant to carbapenem when the zone of in...

Optimal therapy for infections with carbapenem resistant GNB is not well established due to the weakness of data. Patients presenting with bloodstream infections caused by multidrug resistant Klebsiella pneumoniae were treated with a combination treatment. Optimal therapy for infections with carbapenem resistant Gram-negative bacteria is a serious problem in pediatric patients. We presented thr...

background and objective: the production of carbapenemases especially klebsiella pneumoniae carbapenemase (kpc) is the most important mechanism of enzymatic resistance in isolated enterobacteriaceae such as k. pneumoniae. the purpose of this study was detected of the carbapenemase producer k. pneumoniae strains with phenotypic and genotypic methods. method: out of 800 strains, 270 k. pneumoniae...

Introduction: Metallo-beta-lactamase (MBL)-producing Acinetobacter is a therapeutic challenege all over the world. The aims of this study were to determine the prevalence of MBL genes and evaluate the antimicrobial susceptibility profile of carbapenem non-susceptible isolates of Acinetobacter. Material and Method: During a period of 12 months (November 2012 to October 2013) 94 isolates of carba...