The rapid spread of gram-negative bacteria resistance to carbapenems due the production carbapenemases requires new treatment options. activity carbapenem antibiotic biapenem, recently registered in Russia, against producers various was studied comparison with other antibiotics this group. Among NDM-type carbapenemase producers, 77.8% demonstrated clinical susceptibility biapenem; 50.3% and 21....

Background. Practitioners have historically avoided cephalosporins and carbapenems in penicillin allergic patients. Despite recent literature suggesting a lower crosssensitivity than originally reported; practitioners continue to avoid cephalosporins and carbapenems in this patient population. The purpose of this study is to evaluate the tolerability of cephalosporins and carbapenems in patient...

The correlation of the clinical efficacies of ceftazidime-avibactam and comparators (carbapenems) was evaluated against baseline Gram-negative isolates having characterized β-lactam resistance mechanisms from complicated urinary tract infection (cUTI) and complicated intra-abdominal infection (cIAI) phase 2 trials. Enterobacteriaceae displaying ceftriaxone and/or ceftazidime MICs of ≥ 2 μg/ml (...

Carbapenems are one of the β-Lactam antibiotics with a broad spectrum of antibacterial activity. Inappropriate use of this antibiotic can produce resistance strains by production of carbapenemases enzyme. The Klebsiella pneumoniae carbapenemase (KPC) is the most important mechanism of enzymatic resistance seen in Enterobacteriaceae isolated especially Klebsiella pneumoniae. The aim and objectiv...

We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD) properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is longer, were associated with lower mortality. PubMed and Scopus were searched for studies reporting on patients treated with extended (≥3 hours) or continuous (24 hours) versus short-term duration (20-60 minutes) infusions of c...

Carbapenems are the last resort antibiotics for treatment of life-threatening infections. The GES β-lactamases are important contributors to carbapenem resistance in clinical bacterial pathogens. A single amino acid difference at position 170 of the GES-1, GES-2, and GES-5 enzymes is responsible for the expansion of their substrate profile to include carbapenem antibiotics. This highlights the ...

A nationwide survey also established the presence of VIM-2,-5,-6 and-11 and the evolution of a new variant, VIM-18, from this country. 10 These studies indicate the dissemination of various MBL genes in the Indian subcontinent. Although NDM-1 hydrolyses almost all b-lactams efficiently, several of our isolates were found by disc diffusion testing to be susceptible to various carbapenems as well...

objectives the objective of this study was to develop the primers for single and/or multiplex pcr amplification assays for simultaneous identification of class a, class b, and class d carbapenem hydrolyzing β-lactamases in enterobacteriaceae and then to evaluate their efficiency. conclusions we have reported here a reliable method, composed of single and multiplex pcr assays, for screening all ...