Administration of nickel carbonyl to rats by intravenous in jection (2 mg Ni/100 gm body weight) inhibited the induction of hepatic tryptophan pyrrolase by cortisone but not by tryptophan. Cortisone induction was impaired on the day after admin istration of nickel carbonyl. It reached a minimum at 2 days and remained diminished for 5 days. The average activity of hepatic tryptophan pyrrolase in...

Protein carbonyls are widely analysed as a measure of protein oxidation. Several different methods exist for their determination. A previous study had described orders of magnitude variance that existed when protein carbonyls were analysed in a single laboratory by ELISA using different commercial kits. We have further explored the potential causes of variance in carbonyl analysis in a ring stu...

The objective of the present study was to evaluate protein carbonyl concentration as a predictor of AKI development in patients with septic shock and of renal replacement therapy (RRT) and mortality in patients with SAKI. This was a prospective observational study of 175 consecutive patients over the age of 18 years with septic shock upon Intensive Care Unit (ICU) admission. After exclusion of ...

The present study was conducted in patients with cervix and ovarian carcinoma to evaluate the status of oxidative stress biomarkers as protein carbonyl and lipid hydro peroxides. Biomarkers of oxidative stress were measured as protein carbonyl (PC) and total lipid hydro peroxides (LOOH). Newly diagnosed women with carcinoma (n=100; 30-65 years of age) and agematched clinically healthy women (n=...

We apply high-energy-resolution fluorescence-detected (HERFD) X-ray absorption near-edge spectroscopy (XANES) to study iron carbonyl complexes. Mono-, bi-, and tri-nuclear carbonyl complexes and pure carbonyl complexes as well as carbonyl complexes containing hydrocarbon ligands are considered. The HERFD-XANES spectra reveal multiple pre-edge peaks with individual signatures for each complex, w...

The TOR (target of rapamycin) signaling pathway first described in the budding yeast Saccharomyces cerevisiae is highly conserved in eukaryotes effector of cell growth, longevity, and stress response. TOR activation by nitrogen sources, in particular amino acids, is well studied; however its interplay with carbohydrates and carbonyl stress is poorly investigated. Fructose is a more potent glyco...

INTRODUCTION Oxidative stress and carbonyl stress have essential mediatory roles in the development of diabetes and its related complications through increasing free radicals production and impairing antioxidant defense systems. Different chemical and natural compounds have been suggested for decreasing such disorders associated with diabetes. The objectives of the present study were to investi...

During inflammation, the resulting oxidative stress can damage surrounding host tissue, forming protein-carbonyls. The SJL mouse is an experimental animal model used to assess in vivo toxicological responses to reactive oxygen and nitrogen species from inflammation. The goals of this study were to identify the major serum proteins modified with a carbonyl functionality and to identify the types...