and injury are well-known complications of CO poisoning, possibly more prevalent in patients with pre-existing atherosclerotic coronary artery disease. As Dr. Marius-Nunez points out, hypoxic injury is multifactorial, probably related both to CO binding to hemoglobin and also to direct cellular effects of CO. All patients with carbon monoxide exposure should undergo routine electrocardiography ...

The currently recommended prehospital treatment for carbon monoxide (CO) poisoning is administration of 100% O(2). We have shown in dogs that normocapnic hyperpnea with O(2) further accelerates CO elimination. The purpose of this study was to examine the relation between minute ventilation (V E) and the rate of elimination of CO in humans. Seven healthy male volunteers were exposed to CO (400 t...

In this paper, we report a rare and original case of carbon monoxide (CO) mass intoxication. CO is produced in large amounts in industry as well as by gasoline engines, home appliances and the incomplete combustion of wood, natural gas, and tobacco products. It is rapidly absorbed through the lungs and binds to hemoglobin, forming carboxyhemoglobin (COHb), with an affinity 210 times that of oxy...

BACKGROUND Acute high level carbon monoxide (CO) exposure can cause immediate cardio-respiratory arrest in anyone, but the effects of lower level exposures in susceptible persons are less well known. The percentage of CO-bound hemoglobin in blood (carboxyhemoglobin; COHb) is a marker of exposure and potential health outcomes. Indoor air quality guidelines developed by the World Health Organizat...

A 46-year-old woman was found dead in the basement of her home after a fire. External examination of the body showed a wound to the head and soot in the nose and mouth, with soot also found internally in the trachea and bronchi upon autopsy. On questioning by the police, the woman’s husband admitted that he and his wife were having an argument that led to him accidentally knocking her unconscio...

Dichloromethane (DCM) is metabolically converted to carbon monoxide mostly by CYP2E1 in liver, resulting in elevation of blood carboxyhemoglobin (COHb) levels. We investigated the effects of a subtoxic dose of acetaminophen (APAP) on the metabolic elimination of DCM and COHb elevation in adult female rats. APAP, at 500 mg/kg i.p., was not hepatotoxic as measured by a lack of change in serum asp...

To better understand factors that influence carbon monoxide (CO) washout rates, we utilized a multicompartment mathematical model to predict rates of CO uptake, distribution in vascular and extravascular (muscle vs. other soft tissue) compartments, and washout over a range of exposure and washout conditions with varied subject-specific parameters. We fitted this model to experimental data from ...