BACKGROUND The purpose of this study was to compare changes in corneal staining in patients with dry eye after 6 weeks of treatment with Systane® Gel Drops or Refresh Liquigel® lubricant eye drops. METHODS Patients aged ≥18 years with a sodium fluorescein corneal staining sum score of ≥3 in either eye and best-corrected visual acuity of 0.6 logarithm of the minimum angle of resolution or bett...

Egg lectin of Rana japonica, which specifically agglutinates transformed cells but does not agglutinate nontransformed cells and erythrocytes, has been isolated by gel filtration and successive ion-exchange chromatographies on diethylaminoethyl cellulose and carboxymethylcellulose columns and has been characterized as a homogeneous carbohydrate-free protein with a relative molecular weight of 1...

OBJECTIVE To develop a biodegradable, modified-release antibiotic pellet capable of eradicating biofilms as a potential novel treatment for biofilm infections. DESIGN Pellets containing poly(DL-lactic-co-glycolic acid) microparticles, rifampin and clindamycin hydrochloride (3.5%, 7%, or 28% antibiotic by weight), and carrier gel (carboxymethylcellulose or poloxamer 407) were tested in vitro. ...

The most widely-used wall materials for spray-dried microencapsulation have limitations in cost-effectiveness, health benefits and sustainability. Wood hemicelluloses, by-products of the forestry industry, including galactoglucomannans glucuronoxylans potential to be utilized as innovative materials. This study investigated applicability galactoglucomannan glucuronoxylan their mixtures with car...

BACKGROUND Nicotinamide (NA), the active form of vitamin-B3, is hypothesized to have positive effects on the process of wound healing; it has anti-inflammatory, antioxidant, and immunomodulatory properties, as well as an epithelization inducing action. OBJECTIVES In the present study, we aimed to determine the effects of topical administration of NA on skin wounds, based on histomorphometrica...

The formation of polyelectrolyte complexes between carboxymethylcellulose and N-methylated poly(2-vinylpyridine), at a nonstoichiometric mixing ratio, was studied. Various methods, such as viscometry, turbidimetry, electrophoresis, and optical spectroscopy, were used to investigate the complexes with respect to their composition, structure, and stability in aqueous systems of different ionic st...

introduction: idiopathic pulmonary fibrosis (ipf) is a relentlessly progressive and usually fatal lung disease of unknown etiology for which no effective treatments currently exist. in the adults type i and ii pneumocytes, forms components of the alveolar epithelial cells. in this study, we investigated the effect of thalidomide on the alveolar epithelial cells (type i and ii pneumocytes) in th...

Polymeric nanostructures for drug delivery applications including smart hydrogels and stealth micelles have been developed to overcome many obstacles in the way of timing and targeting the delivery to fulfill therapeutic potentiality of chemicals. The purpose of this investigation is to prepare and characterize novel nanoparticle-based colloidal products composed of biocompatible polymers to us...