A 63 year old female presented to hospital with progressive exertional dyspnoea over a 6 month period. In the year preceding her admission, she reported an intercurrent history of abdominal pain, diarrhoea and weight loss. She was found to be hypoxic, the cause for which was initially unclear. A ventilation-perfusion scan identified a right-to-left shunt. Transoesophageal echocardiography (TOE)...

The patient, C.P., is a 59-year-old woman who was diagnosed with metastatic carcinoid of the terminal ileum in May 2003. In June 2003, she underwent an extensive resection including hemicolectomy, cholecystectomy, distal pancreatectomy, and splenectomy with metastatic disease in her pancreas, mesentery, and liver. She had been treated with octreotide, everolimus, oxaliplatin, and multiple hepat...

Carcinoid tumors are relatively rare neuroendocrine malignancies most commonly originating from enterochromaffin cells in the gastrointestinal tract. The incidence is 1 in 100 000 of the general population.1 They usually grow slowly over years, commonly causing no symptoms at all until they become large or have metastasized. Carcinoid tumors of midgut origin may secrete large amounts of vasoact...

Karcinoidové srdeční onemocnění je souhrnné označení pro všechna srdce, která vznikají v důsledku působení neurohumorálních látek produkovaných karcinoidem. Ve většině případů se jedná o poškození pravostranných srdečních chlopní, dominantně insufi cienci trikuspidální chlopně, a vede k pravostrannému srdečnímu selhávání. U menší části pacientů, př...

PURPOSE Effective systemic therapy options for carcinoid tumors are lacking. We conducted in vitro studies and a phase II clinical trial to explore the activity of imatinib in carcinoid tumors. EXPERIMENTAL DESIGN Cells of the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 were treated with increasing concentrations of imatinib using standard p...

PATIENT Female, 67. FINAL DIAGNOSIS Pulmonary carcinoid tumor. SYMPTOMS Abnormal shadow on chest X-ray. MEDICATION -. CLINICAL PROCEDURE -. SPECIALTY Pulmonology. OBJECTIVE Rare disease. BACKGROUND Although pulmonary carcinoid tumors are generally considered to represent a low-grade malignancy, atypical carcinoids are more aggressive than typical carcinoids, metastasizing more com...

comes and angiotensin converting enzyme inhibitor effects in patients with predominantly left ventricular dysfunction and heart failure. Eur J Heart Fail 2014;16:325–333. 24. Eklind-Cervenka M, Benson L, Dahlstrom U, Edner M, Rosenqvist M, Lund LH. Association of candesartan vs. losartan with all-cause mortality in patients with heart failure. JAMA 2011;305:175–182. 25. Lauer MS, D’Agostino RB ...

Bronchial carcinoid tumors account for 1-2% of all primary lung tumors and are separated into 2 subgroups: typical and atypical carcinoids. Atypical carcinoids as intermediate-grade malignancies can metastasize more frequently, thus exhibiting poorer prognosis than the low-grade typical carcinoid tumors. Surgical resection remains the mainstay of treatment for pulmonary carcinoids. Bronchoscopi...

Primary ovarian carcinoid tumors of the ovary are rare and represent less than 0.1% of ovarian malignancy. One of its subtypes is the strumal carcinoid in which the thyroid tissue is seen in intimate association with carcinoid tumor. We here report a 47-year-old woman with strumal carcinoid of the right ovary presented with cessation of menstrual periods in the past 3 months and was referred du...

Carcinoid tumors are associated with the production of a number of bioactive substances that might deposit on the endocardium (endocardial fibroelastosis) and produce cardiac failure. Carcinoid heart disease usually presents as right-sided valvular heart disease. Even if the diagnosis is frequently made by transthoracic echocardiography, cardiac magnetic resonance imaging adds valuable informat...