Ischemic heart disease including myocardial infarction is developing on the basis of several risk-factors and co-morbidities such as obesity, diabetes, hypertension, and hypercholesterolemia. Ischemic heart disease is the leading cause of mortality worldwide, therefore, identification of drug targets for cardioprotection is of great clinical importance. Ischemic preconditioning, postconditionin...

Background—Adenosine (AD) elicits cardioprotection through A1-receptor (A1R) activation.

Physical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases. A partial list of proposed mechanisms for exercise-induced cardioprotection include induction of heat shock proteins, increase in cardiac antioxidant capacity, expression of endoplasmic reticulum stress proteins, anatomical and physiological changes in the coronary arteries, changes ...

The concept of cardioprotection through preconditioning against ischemia-reperfusion (I/R) injury is well known and established. However, among different proposed mechanisms regarding the concept of ischemic preconditioning, protein kinase C (PKC)-mediated cardioprotection through ischemic preconditioning plays a key role in myocardial I/R injury. Thus, this study was designed to find the relat...

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Research, Development and Innovation Office Hungary (NKFIA; NVKP-16-1-2016-0017 Heart Program OTKA-FK 134751); MTA-SE System Pharmacology Research Group, Department Pharmacotherapy, Semmelweis University, H-1089 Budapest, We have previously identified several cardiac microRNAs that...

The present study was designed to investigate the role of estrogen receptor and KATP channel in cardioprotective effect remote aortic preconditioning rat heart. Remote is a phenomenon which brief episodes ischemia reperfusion organs protect target organ against sustained ischemia/ induced injury. Protective effects are well established heart, but their mechanisms still remain be elucidated. rat...

BACKGROUND 5'AMP-activated protein kinase (AMPK), a well-known regulator of cellular energy status, is also implicated in ischemic preconditioning leading to cardioprotection. We hypothesized that AMPK is involved in anesthetic-induced cardioprotection and that this activation is mediated by reactive oxygen species (ROS). METHODS AND RESULTS Isolated Langendorff-perfused rat hearts were subje...

The M(3) subtype of muscarinic acetylcholine receptors (M(3)-mAChR) plays a protective role in myocardial ischemia and microRNAs (miRNAs) participate in many cardiac pathophysiological processes, including ischemia-induced cardiac injury. However, the role of miRNAs in M(3)-mAChR mediated cardioprotection remains unexplored. The present study was designed to identify miRNAs that are involved in...

Endogenous H(2)S is synthesized mainly by cystathionine gamma-lyase in the heart. The present study investigated the role of H(2)S in cardioprotection induced by ischemic preconditioning. We have examined the effect of endogenous H(2)S and exogenous application of NaHS (H(2)S donor) on cardiac rhythm in the isolated rat heart subjected to low-flow ischemia insults as well as cell viability and ...

Recent interest in the annexin 1 field has come from the notion that specific G-protein-coupled receptors, members of the formyl-peptide receptor (FPR) family, appear to mediate the anti-inflammatory actions of this endogenous mediator. Administration of the annexin 1 N-terminal derived peptide Ac2-26 to mice after 25 min ischemia significantly attenuated the extent of acute myocardial injury a...